Showing papers by "University of Virginia published in 2002"
TL;DR: In this article, a menu of paired lottery choices is structured so that the crossover point to the high-risk lottery can be used to infer the degree of risk aversion, and a hybrid "power/expo" utility function with increasing relative and decreasing absolute risk aversion is presented.
Abstract: A menu of paired lottery choices is structured so that the crossover point to the high-risk lottery can be used to infer the degree of risk aversion With normal laboratory payoffs of several dollars, most subjects are risk averse and few are risk loving Scaling up all payoffs by factors of twenty, fifty, and ninety makes little difference when the high payoffs are hypothetical In contrast, subjects become sharply more risk averse when the high payoffs are actually paid in cash A hybrid "power/expo" utility function with increasing relative and decreasing absolute risk aversion nicely replicates the data patterns over this range of payoffs from several dollars to several hundred dollars
4,687 citations
TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
2,227 citations
TL;DR: The connections between time series analysis and nonlinear dynamics, discuss signal-to-noise enhancement, and present some of the novel methods for spectral analysis are described.
Abstract: [1] The analysis of univariate or multivariate time series provides crucial information to describe, understand, and predict climatic variability. The discovery and implementation of a number of novel methods for extracting useful information from time series has recently revitalized this classical field of study. Considerable progress has also been made in interpreting the information so obtained in terms of dynamical systems theory. In this review we describe the connections between time series analysis and nonlinear dynamics, discuss signal-to-noise enhancement, and present some of the novel methods for spectral analysis. The various steps, as well as the advantages and disadvantages of these methods, are illustrated by their application to an important climatic time series, the Southern Oscillation Index. This index captures major features of interannual climate variability and is used extensively in its prediction. Regional and global sea surface temperature data sets are used to illustrate multivariate spectral methods. Open questions and further prospects conclude the review.
2,116 citations
TL;DR: This paper provides the derivation of speckle reducing anisotropic diffusion (SRAD), a diffusion method tailored to ultrasonic and radar imaging applications, and validates the new algorithm using both synthetic and real linear scan ultrasonic imagery of the carotid artery.
Abstract: This paper provides the derivation of speckle reducing anisotropic diffusion (SRAD), a diffusion method tailored to ultrasonic and radar imaging applications. SRAD is the edge-sensitive diffusion for speckled images, in the same way that conventional anisotropic diffusion is the edge-sensitive diffusion for images corrupted with additive noise. We first show that the Lee and Frost filters can be cast as partial differential equations, and then we derive SRAD by allowing edge-sensitive anisotropic diffusion within this context. Just as the Lee (1980, 1981, 1986) and Frost (1982) filters utilize the coefficient of variation in adaptive filtering, SRAD exploits the instantaneous coefficient of variation, which is shown to be a function of the local gradient magnitude and Laplacian operators. We validate the new algorithm using both synthetic and real linear scan ultrasonic imagery of the carotid artery. We also demonstrate the algorithm performance with real SAR data. The performance measures obtained by means of computer simulation of carotid artery images are compared with three existing speckle reduction schemes. In the presence of speckle noise, speckle reducing anisotropic diffusion excels over the traditional speckle removal filters and over the conventional anisotropic diffusion method in terms of mean preservation, variance reduction, and edge localization.
1,816 citations
TL;DR: To identify denial-of-service vulnerabilities, the authors analyzed two effective sensor network protocols that did not initially consider security and demonstrate that consideration of security at design time is the best way to ensure successful network deployment.
Abstract: Sensor networks hold the promise of facilitating large-scale, real-time data processing in complex environments, helping to protect and monitor military, environmental, safety-critical, or domestic infrastructures and resources, Denial-of-service attacks against such networks, however, may permit real world damage to public health and safety Without proper security mechanisms, networks will be confined to limited, controlled environments, negating much of the promise they hold The limited ability of individual sensor nodes to thwart failure or attack makes ensuring network availability more difficult To identify denial-of-service vulnerabilities, the authors analyzed two effective sensor network protocols that did not initially consider security These examples demonstrate that consideration of security at design time is the best way to ensure successful network deployment
1,786 citations
TL;DR: In this article, a methodology was proposed to characterize most, if not all, phosphoproteins from a whole-cell lysate in a single experiment, and a total of 216 peptide sequences defining 383 sites of phosphorylation were determined.
Abstract: Protein kinases are coded by more than 2,000 genes and thus constitute the largest single enzyme family in the human genome. Most cellular processes are in fact regulated by the reversible phosphorylation of proteins on serine, threonine, and tyrosine residues. At least 30% of all proteins are thought to contain covalently bound phosphate. Despite the importance and widespread occurrence of this modification, identification of sites of protein phosphorylation is still a challenge, even when performed on highly purified protein. Reported here is methodology that should make it possible to characterize most, if not all, phosphoproteins from a whole-cell lysate in a single experiment. Proteins are digested with trypsin and the resulting peptides are then converted to methyl esters, enriched for phosphopeptides by immobilized metal-affinity chromatography (IMAC), and analyzed by nanoflow HPLC/electrospray ionization mass spectrometry. More than 1,000 phosphopeptides were detected when the methodology was applied to the analysis of a whole-cell lysate from Saccharomyces cerevisiae. A total of 216 peptide sequences defining 383 sites of phosphorylation were determined. Of these, 60 were singly phosphorylated, 145 doubly phosphorylated, and 11 triply phosphorylated. Comparison with the literature revealed that 18 of these sites were previously identified, including the doubly phosphorylated motif pTXpY derived from the activation loop of two mitogen-activated protein (MAP) kinases. We note that the methodology can easily be extended to display and quantify differential expression of phosphoproteins in two different cell systems, and therefore demonstrates an approach for "phosphoprofiling" as a measure of cellular states.
1,666 citations
TL;DR: Findings in psychology and cognitive neuroscience indicate the importance of affect, although they allow that reasoning can play a restricted but significant role in moral judgment, and point towards a preliminary account of the functional neuroanatomy of moral judgment.
1,565 citations
TL;DR: This new evidence indicates that large source areas of aeolian dust and energetic winter monsoon winds to transport the material must have existed in the interior of Asia by the early Miocene epoch, at least 14 million years earlier than previously thought.
Abstract: The initial desertification in the Asian interior is thought to be one of the most prominent climate changes in the Northern Hemisphere during the Cenozoic era1,2,3,4. But the dating of this transition is uncertain, partly because desert sediments are usually scattered, discontinuous and difficult to date. Here we report nearly continuous aeolian deposits covering the interval from 22 to 6.2 million years ago, on the basis of palaeomagnetic measurements and fossil evidence. A total of 231 visually definable aeolian layers occur as brownish loesses interbedded with reddish soils. This new evidence indicates that large source areas of aeolian dust and energetic winter monsoon winds to transport the material must have existed in the interior of Asia by the early Miocene epoch, at least 14 million years earlier than previously thought3,5. Regional tectonic changes and ongoing global cooling are probable causes of these changes in aridity and circulation in Asia.
1,501 citations
TL;DR: The results suggest that FTY720, after phosphorylation, acts through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking.
1,482 citations
TL;DR: New guidelines for laboratory testing for patients with diabetes mellitus provide specific recommendations that are based on published data or derived from expert consensus, and several analytes have minimal clinical value at present and are not recommended.
Abstract: Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus The quality of the scientific evidence supporting the use of these assays varies substantially
Approach: An expert committee drafted evidence-based recommendations for the use of laboratory analysis in patients with diabetes An external panel of experts reviewed a draft of the guidelines, which were modified in response to the reviewers’ suggestions A revised draft was posted on the Internet and was presented at the AACC Annual Meeting in July, 2000 The recommendations were modified again in response to oral and written comments The guidelines were reviewed by the Professional Practice Committee of the American Diabetes Association
Content: Measurement of plasma glucose remains the sole diagnostic criterion for diabetes Monitoring of glycemic control is performed by the patients, who measure their own plasma or blood glucose with meters, and by laboratory analysis of glycated hemoglobin The potential roles of noninvasive glucose monitoring, genetic testing, autoantibodies, microalbumin, proinsulin, C-peptide, and other analytes are addressed
Summary: The guidelines provide specific recommendations based on published data or derived from expert consensus Several analytes are of minimal clinical value at the present time, and measurement of them is not recommended
1,481 citations
TL;DR: The substantial regional variability in reactive nitrogen creation, its degree of distribution, and the likelihood of increased rates of reactive-N formation (especially in Asia in the future creates a situation that calls for the development of a Total Reactive Nitrogen Approach that will optimize food and energy production and protect environmental systems.
Abstract: This paper examines the impact of food and energy production on the global N cycle by contrasting N flows in the late-19th century with those of the late-20th century. We have a good understanding of the amounts of reactive N created by humans, and the primary points of loss to the environment. However, we have a poor understanding of nitrogen's rate of accumulation in environmental reservoirs, which is problematic because of the cascading effects of accumulated N in the environment. The substantial regional variability in reactive nitrogen creation, its degree of distribution, and the likelihood of increased rates of reactive-N formation (especially in Asia) in the future creates a situation that calls for the development of a Total Reactive Nitrogen Approach that will optimize food and energy production and protect environmental systems.
Oregon State University1, University of Bayreuth2, University of California, Berkeley3, Climate Monitoring and Diagnostics Laboratory4, Institut national de la recherche agronomique5, University of Minnesota6, Wageningen University and Research Centre7, University of California, Davis8, University of Virginia9, Swedish University of Agricultural Sciences10, United States Department of Agriculture11, University of Antwerp12, University of Edinburgh13, Technical University of Denmark14, Duke University15, Tuscia University16, Oak Ridge National Laboratory17, University of Colorado Boulder18, Harvard University19, San Diego State University20, University of Nebraska–Lincoln21, University of Helsinki22
TL;DR: The authors compared seasonal and annual estimates of CO2 and water vapor exchange across sites in forests, grasslands, crops, and tundra that are part of an international network called FLUXNET, and investigated the responses of vegetation to environmental variables.
TL;DR: Results show that entropy falls before clinical signs of neonatal sepsis and that missing points are well tolerated, and proposes more informed selection of parameters and reexamination of studies where approximate entropy was interpreted solely as a regularity measure.
Abstract: Abnormal heart rate characteristics of reduced variability and transient decelerations are present early in the course of neonatal sepsis. To investigate the dynamics, we calculated sample entropy, a similar but less biased measure than the popular approximate entropy. Both calculate the probability that epochs of window length m that are similar within a tolerance r remain similar at the next point. We studied 89 consecutive admissions to a tertiary care neonatal intensive care unit, among whom there were 21 episodes of sepsis, and we performed numerical simulations. We addressed the fundamental issues of optimal selection of m and r and the impact of missing data. The major findings are that entropy falls before clinical signs of neonatal sepsis and that missing points are well tolerated. The major mechanism, surprisingly, is unrelated to the regularity of the data: entropy estimates inevitably fall in any record with spikes. We propose more informed selection of parameters and reexamination of studies where approximate entropy was interpreted solely as a regularity measure.
TL;DR: In this article, the authors report a repeated measures field study that captures complaining customers' perceptions of their overall satisfaction with the firm, likelihood of word-of-mouth recommendations, and repurchase intent during a 20-month span that includes two service failures and recovery attempts.
Abstract: The authors report a repeated measures field study that captures complaining customers’ perceptions of their overall satisfaction with the firm, likelihood of word-of-mouth recommendations, and repurchase intent during a 20-month span that includes two service failures and recovery attempts. The findings suggest that though satisfactory recoveries can produce a “recovery paradox” after one failure, they do not trigger such paradoxical increases after two failures. Furthermore, “double deviations” can occur following two consecutive unsatisfactory recoveries or following an unsatisfactory recovery in response to a second failure. The findings indicate that customers reporting an unsatisfactory recovery followed by a satisfactory recovery reported significantly higher ratings at the second postrecovery period than did customers reporting the opposite recovery sequence. The outcome of the second recovery also demonstrated a significant influence on customer ratings (positively if the recovery was sa...
TL;DR: In this article, the authors explore how the introduction of habit preferences into the simple intertemporal consumption-based capital asset pricing model "solves" the equity premium and risk-free rate puzzles.
TL;DR: A subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro is described and it is suggested that these cells may represent a regulatory subset of APCs in humans.
Abstract: Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
TL;DR: Two experiments employed image-based tasks to test the hypothesis that happier moods promote a greater focus on the forest and sadder moods a greaterfocus on the trees, based on the idea that in task situations, affective cues may be experienced as task-relevant information, which then influences global versus local attention.
Abstract: Two experiments employed image-based tasks to test the hypothesis that happier moods promote a greater focus on the forest and sadder moods a greater focus on the trees. The hypothesis was based on the idea that in task situations, affective cues may be experienced as task-relevant information, which then influences global versus local attention. Using a serial-reproduction paradigm, Experiment 1 showed that individuals in sad moods were less likely than those in happier moods to use an accessible global concept to guide attempts to reproduce a drawing from memory. Experiment 2 investigated the same hypothesis by assessing the use of global and local attributes to classify geometricfigures. As predicted, individuals in sad moods were less likely than those in happier moods to classify figures on the basis of globalfeatures.
TL;DR: In this article, the MODIS Fire Rapid Response System and a web-based mapping system for enhanced distribution are described, and the next steps for MODIS fire products are outlined and an example is given for southern Africa of how this product can be used in modeling pyrogenic emissions.
University of Rochester1, Cornell University2, University of California, San Diego3, Emory University4, Rush University Medical Center5, Washington University in St. Louis6, Johns Hopkins University7, University of Pennsylvania8, Albany Medical College9, University of Virginia10, University of Southern California11
TL;DR: Coenzyme Q10 appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study.
Abstract: Background Parkinson disease (PD) is a degenerative neurological disorder for which no treatment has been shown to slow the progression. Objective To determine whether a range of dosages of coenzyme Q10is safe and well tolerated and could slow the functional decline in PD. Design Multicenter, randomized, parallel-group, placebo-controlled, double-blind, dosage-ranging trial. Setting Academic movement disorders clinics. Patients Eighty subjects with early PD who did not require treatment for their disability. Interventions Random assignment to placebo or coenzyme Q10at dosages of 300, 600, or 1200 mg/d. Main Outcome Measure The subjects underwent evaluation with the Unified Parkinson Disease Rating Scale (UPDRS) at the screening, baseline, and 1-, 4-, 8-, 12-, and 16-month visits. They were followed up for 16 months or until disability requiring treatment with levodopa had developed. The primary response variable was the change in the total score on the UPDRS from baseline to the last visit. Results The adjusted mean total UPDRS changes were +11.99 for the placebo group, +8.81 for the 300-mg/d group, +10.82 for the 600-mg/d group, and +6.69 for the 1200-mg/d group. ThePvalue for the primary analysis, a test for a linear trend between the dosage and the mean change in the total UPDRS score, was .09, which met our prespecified criteria for a positive trend for the trial. A prespecified, secondary analysis was the comparison of each treatment group with the placebo group, and the difference between the 1200-mg/d and placebo groups was significant (P= .04). Conclusions Coenzyme Q10was safe and well tolerated at dosages of up to 1200 mg/d. Less disability developed in subjects assigned to coenzyme Q10than in those assigned to placebo, and the benefit was greatest in subjects receiving the highest dosage. Coenzyme Q10appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study.
TL;DR: In this paper, the authors define organizational analogs for Mead's "I" and "me" and explain how these two phases of organizational identity are related, and propose an organizational identity model based on four processes linking organizational identity to culture and image.
Abstract: Although many organizational researchers make reference to Mead’s theory of social identity, none have explored how Mead’s ideas about the relationship between the ‘I’ and the ‘me’ might be extended to identity processes at the organizational level of analysis. In this article we define organizational analogs for Mead’s ‘I’ and ‘me’ and explain how these two phases of organizational identity are related. In doing so, we bring together existing theory concerning the links between organizational identities and images, with new theory concerning how reflection embeds identity in organizational culture and how identity expresses cultural understandings through symbols. We offer a model of organizational identity dynamics built on four processes linking organizational identity to culture and image. Whereas the processes linking identity and image (mirroring and impressing) have been described in the literature before, the contribution of this article lies in articulation of the processes linking identity and c...
TL;DR: This research effort seeks to examine the theoretical foundation of nonparametric regression and to answer the question of whether non parametric regression based on heuristically improved forecast generation methods approach the single interval traffic flow prediction performance of seasonal ARIMA models.
Abstract: Single point short-term traffic flow forecasting will play a key role in supporting demand forecasts needed by operational network models. Seasonal autoregressive integrated moving average (ARIMA), a classic parametric modeling approach to time series, and nonparametric regression models have been proposed as well suited for application to single point short-term traffic flow forecasting. Past research has shown seasonal ARIMA models to deliver results that are statistically superior to basic implementations of nonparametric regression. However, the advantages associated with a data-driven nonparametric forecasting approach motivate further investigation of refined nonparametric forecasting methods. Following this motivation, this research effort seeks to examine the theoretical foundation of nonparametric regression and to answer the question of whether nonparametric regression based on heuristically improved forecast generation methods approach the single interval traffic flow prediction performance of seasonal ARIMA models.
National Institutes of Health1, University of Alabama at Birmingham2, University of California, Los Angeles3, Case Western Reserve University4, University of Utah5, New York Medical College6, Virginia Commonwealth University7, Loyola University Chicago8, University of Kentucky9, University of Virginia10, University of Pennsylvania11, Rowan University12, University of Florida13, Mayo Clinic14, Harvard University15, Université de Montréal16, Duke University17, University of Ottawa18, University of Arkansas at Little Rock19
TL;DR: Voriconazole is a suitable alternative to amphotericin B preparations for empirical antifungal therapy in patients with neutropenia and persistent fever in a randomized, international, multicenter trial.
Abstract: Background Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal triazoles offer a potentially safer and effective alternative. Methods In a randomized, international, multicenter trial, we compared voriconazole, a new second-generation triazole, with liposomal amphotericin B for empirical antifungal therapy. Results A total of 837 patients (415 assigned to voriconazole and 422 to liposomal amphotericin B) were evaluated for success of treatment. The overall success rates were 26.0 percent with voriconazole and 30.6 percent with liposomal amphotericin B (95 percent confidence interval for the difference, –10.6 to 1.6 percentage points); these rates were independent of the administration of antifungal prophylaxis or the use of colony-stimulating factors. There were fewer documented breakthrough fungal infections in patients treated with voriconazole than in those treated with liposomal a...
TL;DR: In this paper, the authors proposed a model of the effects of perceived justice on customer satisfaction and intent following a service or product failure and a recovery attempt and tested the model using two field studies that captured customer perceptions over time, and the results largely support the model's path estimates and explanatory power.
TL;DR: An effort to develop a standardized classification system for neck dissection was undertaken and the final product was published in the ARCHIVES 1 and as a monograph 2 by the AAO-HNS in 1991.
Abstract: Since the first description of the radical neck dissection by George Crile almost a century ago, many variations and modifications of the procedure have been added. These include the functional neck dissection, the modified radical neck dissection, and various selective neck dissections. In response to the need for an organized approach in describing these operations, the Committee for Head and Neck Surgery and Oncology of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) in 1988 initiated an effort to develop a standardized classification system for neck dissection (Table 1). During this process, input was obtained from the Education Committee of the American Society for Head and Neck Surgery (ASHNS) and its Council. The final product, endorsed by the ASHNS and the AAO-HNS, was published in the ARCHIVES 1 and as a monograph 2 by the AAO-HNS in 1991.
Journal Article•
University of Minnesota1, University of Virginia2, Memorial Hospital of Rhode Island3, University of Rochester4, University Of Tennessee System5, Baylor College of Medicine6, University of Michigan7, Cincinnati Children's Hospital Medical Center8, Albany Medical College9, State University of New York Upstate Medical University10, University of California, San Francisco11
TL;DR: The integrated model specifically examines the influence of pre-training and training environment interventions (termed user acceptance enablers) to understand how user perceptions are formed prior to system implementation.
Abstract: Building on recent unique, yet potentially complementary, approaches to understanding the formation of user perceptions about technology (Venkatesh, 1999; Venkatesh & Speier, 1999), the present work reanalyzes the data from both studies to develop an integrated model of technology acceptance. The integrated model specifically examines the influence of pre-training and training environment interventions (termed user acceptance enablers) to understand how user perceptions are formed prior to system implementation. The model is then further extended and tested using longitudinal data in a field setting. The results indicate that the integrated model emerged as a better predictor of user behavior when compared to the existing models.
TL;DR: The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed.
Abstract: BACKGROUND Multiple laboratory tests are used to diagnose and manage patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these tests varies substantially. APPROACH An expert committee compiled evidence-based recommendations for the use of laboratory testing for patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. Draft guidelines were posted on the Internet and presented at the 2007 Arnold O. Beckman Conference. The document was modified in response to oral and written comments, and a revised draft was posted in 2010 and again modified in response to written comments. The National Academy of Clinical Biochemistry and the Evidence-Based Laboratory Medicine Committee of the American Association for Clinical Chemistry jointly reviewed the guidelines, which were accepted after revisions by the Professional Practice Committee and subsequently approved by the Executive Committee of the American Diabetes Association. CONTENT In addition to long-standing criteria based on measurement of plasma glucose, diabetes can be diagnosed by demonstrating increased blood hemoglobin A 1c (HbA 1c ) concentrations. Monitoring of glycemic control is performed by self-monitoring of plasma or blood glucose with meters and by laboratory analysis of HbA 1c . The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. SUMMARY The guidelines provide specific recommendations that are based on published data or derived from expert consensus. Several analytes have minimal clinical value at present, and their measurement is not recommended.
TL;DR: A rough conceptual map of the terrain of public health ethics is attempted to provide a recognition of the multidimensional nature of the determinants of health; and a focus on the complex interactions of many factors in developing effective interventions.
Abstract: , 30 (2002): 170 –178.© 2002 by the American Society of Law, Medicine & Ethics.ublic health ethics, like the field of public health itaddresses, traditionally has focused more on practiceand particular cases than on theory, with the resultthat some concepts, methods, and boundaries remain largelyundefined. This paper attempts to provide a rough concep-tual map of the terrain of public health ethics. We begin bybriefly defining public health and identifying general fea-tures of the field that are particularly relevant for a discussionof public health ethics.Public health is primarily concerned with the health ofthe entire population, rather than the health of individuals.Its features include an emphasis on the promotion of healthand the prevention of disease and disability; the collectionand use of epidemiological data, population surveillance,and other forms of empirical quantitative assessment; a rec-ognition of the multidimensional nature of the determinantsof health; and a focus on the complex interactions of manyfactors — biological, behavioral, social, and environmental— in developing effective interventions.How can we distinguish public health from medicine?While medicine focuses on the treatment and cure of indi-vidual patients, public health aims to understand andameliorate the causes of disease and disability in a popula-tion. In addition, whereas the physician-patient relationshipis at the center of medicine, public health involves interac-tions and relationships among many professionals andmembers of the community as well as agencies of govern-ment in the development, implementation, and assessmentof interventions. From this starting point, we can suggestthat public health systems consist of all the people and ac-tions, including laws, policies, practices, and activities, thathave the primary purpose of protecting and improving thehealth of the public.
TL;DR: It is shown that Ras relays the NMDA-R and CaMKII signaling that drives synaptic delivery of AMPA-Rs during long-term potentiation, and Rap mediates NMda-R-dependent removal of synaptic AMpa-Rs that occurs duringLong-term depression.
TL;DR: Cell migration is an integrated process that requires the continuous, coordinated formation and disassembly of adhesions, and the technology to facilitate significant advances in this area is now in place.
Abstract: Cell migration is an integrated process that requires the continuous, coordinated formation and disassembly of adhesions. These processes are complex and require a regulated interaction of numerous molecules, and the activation of specific signalling pathways. Even though understanding these processes is challenging, important insights are beginning to emerge, and the technology to facilitate significant advances in this area is now in place.