A roadmap for the Human Developmental Cell Atlas
Muzlifah Haniffa,Muzlifah Haniffa,Deanne Taylor,Deanne Taylor,Sten Linnarsson,Bruce J. Aronow,Gary D. Bader,Roger A. Barker,Pablo G. Camara,J. Gray Camp,Alain Chédotal,Andrew J. Copp,Heather C. Etchevers,Paolo Giacobini,Berthold Göttgens,Guoji Guo,Ania Hupalowska,Kylie R. James,Emily Kirby,Arnold R. Kriegstein,Joakim Lundeberg,John C. Marioni,Kerstin B. Meyer,Kathy K. Niakan,Kathy K. Niakan,Mats Nilsson,Bayanne Olabi,Dana Pe'er,Aviv Regev,Aviv Regev,Aviv Regev,Jennifer Rood,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Rahul Satija,Sarah A. Teichmann,Sarah A. Teichmann,Barbara Treutlein,Roser Vento-Tormo,Simone Webb +39 more
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TLDR
The Human Developmental Cell Atlas (HDCA) project as discussed by the authors aims to create a comprehensive reference map of cells during development by mapping and modelling human development using state-of-the-art technologies.Abstract:
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development. This Perspective outlines the Human Developmental Cell Atlas initiative, which uses state-of-the-art technologies to map and model human development across gestation, and discusses the early milestones that have been achieved.read more
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Cells of the human intestinal tract mapped across space and time.
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TL;DR: The case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs is discussed.
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Modelling human blastocysts by reprogramming fibroblasts into iBlastoids
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TL;DR: In this paper, a scalable and tractable system was developed to model human blastocyst biology, iBlastoids, which can give rise to pluripotent and trophoblast stem cells and are capable of modeling, in vitro, several aspects of the early stage of implantation.
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Blastocyst-like structures generated from human pluripotent stem cells
Leqian Yu,Yulei Wei,Yulei Wei,Jialei Duan,Daniel A. Schmitz,Masahiro Sakurai,Lei Wang,Kunhua Wang,Shuhua Zhao,Gary C. Hon,Jun Wu +10 more
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