Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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Classifying collective cancer cell invasion
TL;DR: A framework for addressing potential mechanisms, experimental strategies and technical challenges to study collective cancer cell invasion is proposed.
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis,Shannon K. Hughes-Alford,Joseph L. Charest,John S. Condeelis,Frank B. Gertler,Roger D. Kamm +5 more
TL;DR: Evidence is provided that the endothelium poses a barrier to tumor cell intravasation that can be regulated by factors present in the tumor microenvironment.
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Differential macrophage programming in the tumor microenvironment.
TL;DR: Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.
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Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
References
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Journal Article
Chemotaxis and Chemokinesis of Malignant Mesothelioma Cells to Multiple Growth Factors
Zhiwen Liu,Julius Klominek +1 more
TL;DR: Findings provide evidence that multiple growth factors can induce chemotaxis and chemokinesis in malignant mesothelioma cell lines, and may contribute to the understanding of the highly invasive behavior of malignant Mesoteliomas in vivo.
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Gradient sensing in defined chemotactic fields
TL;DR: Correlation of the size and persistence of RasGTP patches with extension of pseudopods may set the rules for understanding how the signal transduction mechanisms convert a weak external signal to a strong directional bias.
Journal Article
Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T-Cell Leukemia Cell Invasion
Toshihisa Hayashibara,Yasuaki Yamada,Takayuki Miyanishi,Hiroyuki Mori,Tatsuroh Joh,Takahiro Maeda,Naoki Mori,Tetsuo Maita,Shimeru Kamihira,Masao Tomonaga +9 more
TL;DR: A possible autocrine mechanism involving VEGF operating by way of Flt-1 is proposed, in which ATL cells up-regulate their own chemotaxis to facilitate their invasion into various organs.
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cAMP production by adenylyl cyclase G induces prespore differentiation in Dictyostelium slugs.
TL;DR: It is shown that adenylyl cyclase G (ACG) protein is upregulated in prespore tissue after aggregation, with ACB capable of partially taking over this function in its absence.
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Efficient generation of gene knockout plasmids for Dictyostelium discoideum using one-step cloning
TL;DR: The use of one-step cloning for the fast and efficient generation of deletion vectors that are produced in a one- step reaction by inserting two PCR products into an organism-specific, generic acceptor system is described.
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