Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
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Balanced ubiquitination determines cellular responsiveness to extracellular stimuli
Akiko Mukai,Miki Yamamoto-Hino,Miki Yamamoto-Hino,Miki Yamamoto-Hino,Masayuki Komada,Hideyuki Okano,Satoshi Goto,Satoshi Goto,Satoshi Goto +8 more
TL;DR: How ubiquitination regulates receptor presentation at the cell surface for the detection of extracellular signal strength is reviewed.
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Epidermal growth factor promotes a mesenchymal over an amoeboid motility of MDA-MB-231 cells embedded within a 3D collagen matrix
TL;DR: It is reported that EGF promotes a mesenchymal over an amoeboid motility phenotype using a malignant breast tumor cell line embedded within a 3D collagen matrix, and this work suggests a potential visual cue for diagnosing invasive states of breast cancer cells.
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Optimizing leading edge F-actin labeling using multiple actin probes, fixation methods and imaging modalities.
TL;DR: Evaluation of commonly used live-cell probes provides evidence for actin filament bias, with TagRFP- lifeact excluded from lamellipodia, but not mEGFP-Lifeact or F-tractin-EGFP.
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FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas
Naomi Egbivwie,Julia V. Cockle,Matthew P. Humphries,Azzam Ismail,Filomena Esteves,Claire Taylor,Katherine Karakoula,Ruth Morton,Tracy Warr,Susan C Short,Anke Brüning-Richardson +10 more
TL;DR: The clinical relevance of FGFR1 expression, cell migration in low and high grade pediatric gliomas and the role ofFGFR1 in cell migration/invasion as a potential chemotherapeutic target is explored and the findings support further research to target FG FR1 signaling in pediatricgliomas.
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Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis
TL;DR: In this article, a review highlights nanomaterial-based approaches in the detection and treatment of cancer metastasis, with a special focus on the evaluation of nanostructure effects on cell migration, invasion, and angiogenesis in the tumor microenvironment.
References
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Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
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