Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Book ChapterDOI
Dictyosteliumdiscoideum as a Model in Biomedical Research
TL;DR: Questions about D. discoideum, which have been traditionally used to understand basic principles of cell and developmental biology and now has also become a useful system in biomedical research, are addressed in this chapter.
Journal ArticleDOI
Distinguishing Convective and Powered Motion in Self-Propelled Colloids
TL;DR: In this paper, the statistical properties of translational and rotational motions of catalytic colloidal particles are analyzed to distinguish active chemotaxis from passive advection by bulk flow.
Journal ArticleDOI
Cell Trafficking at the Intersection of the Tumor–Immune Compartments
TL;DR: The biophysical and biomolecular basis for the migration of immune and tumor cells and their associated reciprocal regulatory network are reviewed and ongoing attempts to translate this knowledge into the clinic are described.
Journal ArticleDOI
Keratinocyte Motility Is Affected by UVA Radiation—A Comparison between Normal and Dysplastic Cells
Cristina M. Niculiţe,Marina Tamara Nechifor,Andreea O. Urs,Laura Olariu,Laura Cristina Ceafalan,Mircea Leabu +5 more
TL;DR: After UVA exposure HaCaT and DOK cells showed a different behavior in terms of adherence, spreading, motility, proliferation, and actin cytoskeleton dynamics, with the dyplastic keratinocytes being more sensitive.
References
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Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
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