Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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Classifying collective cancer cell invasion
TL;DR: A framework for addressing potential mechanisms, experimental strategies and technical challenges to study collective cancer cell invasion is proposed.
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis,Shannon K. Hughes-Alford,Joseph L. Charest,John S. Condeelis,Frank B. Gertler,Roger D. Kamm +5 more
TL;DR: Evidence is provided that the endothelium poses a barrier to tumor cell intravasation that can be regulated by factors present in the tumor microenvironment.
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Differential macrophage programming in the tumor microenvironment.
TL;DR: Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.
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Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
References
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The EGF/CSF-1 Paracrine Invasion Loop can be Triggered by Heregulin Beta 1 and CXCL12
Lorena Hernandez,Tatiana Smirnova,Dmitriy Kedrin,Jeffrey B. Wyckoff,Liyin Zhu,E. Richard Stanley,Dianne Cox,William J. Muller,Jeffrey W. Pollard,Nico van Rooijen,Jeffrey E. Segall +10 more
TL;DR: It is reported that invasion induced by other ligands also relies on this EGF/CSF-1 paracrine invasive loop, and a stromal/tumor interaction is identified that acts as an engine underlying invasioninduced by multiple ligands.
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A common cofilin activity cycle in invasive tumor cells and inflammatory cells.
TL;DR: An overview of cofilin activation in both tumor cells and inflammatory cells is given, and it is proposed that all of the data can be explained by a single activity-cycle model.
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CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor.
TL;DR: The CXC‐chemokines, which have been shown to promote the migration of neutrophils and carcinoma cells, are candidates to influence prostate carcinoma‐cell invasion.
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Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging
David Entenberg,Jeffrey B. Wyckoff,Bojana Gligorijevic,Evanthia T. Roussos,Vladislav V. Verkhusha,Jeffrey W. Pollard,John S. Condeelis +6 more
TL;DR: This work presents a procedure for constructing a two-laser multiphoton microscope that extends the wavelength range of excitation light, expands the number of simultaneously usable fluorophores and markedly increases signal to noise via 'over-clocking' of detection.
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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.
Vera DesMarais,Hideki Yamaguchi,Matthew G. Oser,Lilian Soon,Ghassan Mouneimne,Corina Sarmiento,Robert J. Eddy,John S. Condeelis +7 more
TL;DR: In this paper, invadopodia formation on glass requires N-WASP and cortactin but not microtubules, and depletion of either protein inhibits chemotaxis of cells towards EGF.
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