Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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3D bioprinting technology to mimic the tumor microenvironment: tumor-on-a-chip concept
Hadi Samadian,Samira Jafari,M.R. Sepand,Loghman Alaei,S. Sadegh Malvajerd,Mehdi Jaymand,F. Ghobadinezhad,Fatemeh Jahanshahi,Michael R. Hamblin,Hossein Derakhshankhah,Zhila Izadi +10 more
TL;DR: A recent review summarizes progress in the area of 3D bioprinting utility for mimicking the tumor microenvironment, and studying the physicochemical/biological factors for new and improved therapeutic and diagnostic applications as mentioned in this paper.
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Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy.
Sahar Jafari Nivlouei,Sahar Jafari Nivlouei,Madjid Soltani,João Carvalho,Rui D. M. Travasso,Mohammad Reza Salimpour,Ebrahim Shirani +6 more
TL;DR: In this paper, the authors introduced a multiscale simulation that models the cellular interactions and cell behavior as a consequence of the activation of oncogenes and deactivation of gene signaling pathways within each cell.
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Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease.
TL;DR: The role of CXCR4 and its important cell signaling pathways in the pathogenesis of liver disease and summarizes the targeted therapeutic studies conducted to date is discussed in this article, where an in-depth understanding of CxCR4-mediated signaling pathway and its role in liver disease is critical to identifying potential therapeutic strategies.
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SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression.
Aftab Alam,Nandaraj Taye,Sonal Patel,Milind M Thube,Jayati Mullick,Vibhuti Kumar Shah,Richa Pant,Tanaya Roychowdhury,Nilanjan Banerjee,Subhrangsu Chatterjee,R. Bhattacharya,Rini Roy,Ashis Mukhopadhyay,Devraj Mogare,Samit Chattopadhyay +14 more
TL;DR: It is established that increased expression of SMAR1 in cancers can positively regulate MHC I surface expression thereby leading to higher chances of tumor regression and elimination of cancer cells.
Posted ContentDOI
Role of neutrophil extracellular traps in regulation of lung cancer invasion and metastasis: Structural Insights from a Computational Model
TL;DR: How stimulated neutrophils with different N1 and N2 landscapes shape the metastatic potential of the lung cancers is investigated to investigate the fundamental mechanism of NET-mediated invasion of cancer cells and the impact of internal and external heterogeneity on the migration patterning of tumour cells and their response to different treatment schedules.
References
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