Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability
Junwei Zhao,Fang Fang,Yi Guo,Tai-Lin Zhu,Yun-Yun Yu,Fan-Fei Kong,Lingfei Han,Dong-Sheng Chen,Fang Li +8 more
TL;DR: In this article, the authors explored the mechanisms and consequences of high risk human papilloma virus (HPV) integration in women with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (SCC).
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Sequential culture on biomimetic nanoclay scaffolds forms three-dimensional tumoroids.
Kalpana S. Katti,Shahajahan Molla,Fataneh Karandish,Manas K. Haldar,Sanku Mallik,Dinesh R. Katti +5 more
TL;DR: The PCL/HAPclay scaffold system seeded with the sequential culture of hMSCs, and HPCCs presents a good model system for study of the interactions between prostate cancer cells and bone microenvironment.
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Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer.
TL;DR: In this paper, the authors presented gradient sensing and the resulting chemotactic behavior, in a "cue-signal-response" framework and suggest methods for utilizing recently reported experimental methods in data-driven modeling ventures.
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From a discrete model of chemotaxis with volume-filling to a generalized Patlak-Keller-Segel model.
TL;DR: A general form of the celebrated Patlak–Keller–Segel (PKS) model of chemotaxis can be formally derived as the appropriate continuum limit of this discrete model and the outcomes of the two models faithfully replicate those of the classical PKS model in a suitable asymptotic regime.
Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines
Viktor A. Adalsteinsson,Narmin Tahirova,Naren Tallapragada,Xiaosai Yao,Liam Campion,Alessandro Angelini,Thomas B. Douce,Brittany A. Bowman,Christina A. Williamson,J. Christopher Love,Cindy Huang,Douglas S. Kwon,Karl Dane Wittrup +12 more
TL;DR: The secretions of ELR+CXC chemokines from thousands of single colorectal tumor and stromal cells, using an array of subnanoliter wells and a technique called microengraving to characterize both the rates of secretion of several factors at once and the numbers of cells secreting each chemokine.
References
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