Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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Classifying collective cancer cell invasion
TL;DR: A framework for addressing potential mechanisms, experimental strategies and technical challenges to study collective cancer cell invasion is proposed.
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis,Shannon K. Hughes-Alford,Joseph L. Charest,John S. Condeelis,Frank B. Gertler,Roger D. Kamm +5 more
TL;DR: Evidence is provided that the endothelium poses a barrier to tumor cell intravasation that can be regulated by factors present in the tumor microenvironment.
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Differential macrophage programming in the tumor microenvironment.
TL;DR: Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.
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Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
References
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Tumor self-seeding by circulating cancer cells
Miyoung Kim,Thordur Oskarsson,Swarnali Acharyya,Don X. Nguyen,Xiang Zhang,Larry Norton,Joan Massagué +6 more
TL;DR: Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.
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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
TL;DR: Two modes of tumour-cell motility in 3D matrices that involve different usage of Rho signalling are identified and combined blockade of extracellular proteases and ROCK negates the ability of tumours to switch between modes of motility and synergises to prevent tumour cell invasion.
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Systemic spread is an early step in breast cancer.
Yves Hüsemann,Jochen B. Geigl,Falk Schubert,Piero Musiani,Manfred Meyer,Elke Burghart,Guido Forni,Roland Eils,Tanja Fehm,Gert Riethmüller,Christoph Klein +10 more
TL;DR: It is shown that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women, and release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis.
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A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.
Jeffrey B. Wyckoff,Weigang Wang,Elaine Y. Lin,Yarong Wang,Fiona J. Pixley,E. Richard Stanley,Thomas Graf,Jeffrey W. Pollard,Jeffrey E. Segall,John S. Condeelis +9 more
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Macrophage polarization in tumour progression.
Antonio Sica,Paola Larghi,Alessandra Mancino,Luca Rubino,Chiara Porta,Maria Grazia Totaro,Monica Rimoldi,Subhra K. Biswas,Paola Allavena,Alberto Mantovani,Alberto Mantovani +10 more
TL;DR: Recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer are discussed.
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