Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling
TL;DR: It is suggested that fibrotic microenvironment may enhance the metastatic seeding of tumor cells in the lung by chemoattracting tumor cells and inhibiting their apoptosis via activating the FN1/SPP1-ITGAV signaling.
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Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging.
James K. Williams,David Entenberg,Yarong Wang,Alvaro Avivar-Valderas,Michael R. Padgen,Ashley Clark,Julio A. Aguirre-Ghiso,James Castracane,John S. Condeelis +8 more
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Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice
Shi-Long Zhang,Bing Han,Yu-Qin Mao,Zheng-Yan Zhang,Zhan-Ming Li,Chao-Yue Kong,You Wu,Guoqiang Chen,Li-Shun Wang +8 more
TL;DR: Novel insights are offered into the mechanism by which gut microbiota shaped the outcome of cancer immunotherapy and, more importantly, the novel strain L. paracasei sh2020 might serve as an easy and effective way to promote anti-PD-1 effect in clinical practice.
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A microfluidic device for studying the production of reactive oxygen species and the migration in lung cancer cells under single or coexisting chemical/electrical stimulation
TL;DR: A microfluidic chip was developed for studying the production of ROS and the migration in lung cancer cells under single or coexisting chemical/electrical stimulation, and provides an in vitro platform mimicking the physiological condition where cells are under circulating conditions and are subject to controllable chemical/physical stimuli.
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Visualizing cancer extravasation: from mechanistic studies to drug development
Xiao Cheng,Ke Cheng,Ke Cheng +2 more
TL;DR: This review focuses on recent progress in cancer extravasation visualization techniques, including the development of both in vitro and in vivo cancerExtravasation models, that shed light on the underlying mechanisms.
References
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