Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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Classifying collective cancer cell invasion
TL;DR: A framework for addressing potential mechanisms, experimental strategies and technical challenges to study collective cancer cell invasion is proposed.
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis,Shannon K. Hughes-Alford,Joseph L. Charest,John S. Condeelis,Frank B. Gertler,Roger D. Kamm +5 more
TL;DR: Evidence is provided that the endothelium poses a barrier to tumor cell intravasation that can be regulated by factors present in the tumor microenvironment.
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Differential macrophage programming in the tumor microenvironment.
TL;DR: Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.
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Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
References
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PI 3-Kinases and PTEN: How Opposites Chemoattract
Frank I. Comer,Carole A. Parent +1 more
TL;DR: Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.
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Regulator of G-protein signaling (RGS) proteins in cancer biology
TL;DR: This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in R GS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types.
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CSF‐1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract
TL;DR: CSF‐1 and its receptor have been more recently shown to be expressed by carcinomas of the breast and other epithelia of the female reproductive tract where activation of the receptor by ligand produced by the tumor cells or by stromal elements stimulates tumor cell invasion by a urokinase‐dependent mechanism.
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WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.
Corina Sarmiento,Weigang Wang,Athanassios Dovas,Hideki Yamaguchi,Mazen Sidani,Mirvat El-Sibai,Vera DesMarais,Holly A. Holman,Susan M. Kitchen,Jonathan M. Backer,Art Alberts,John S. Condeelis +11 more
TL;DR: Data show that coordinate regulation between the WASP family and mDia proteins controls the balance between lamellar and lamellipodial protrusion activity.
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Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion.
Leo S. Price,John G. Collard +1 more
TL;DR: The balance of Rac and Rho activities and intracellular localization appears to be critical in determining the cellular phenotype.
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