Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration
TL;DR: A dynamic crosstalk between EGF mediated chemotaxis and CIL guide metastatic breast cancer cell motility, whereby cells become progressively insensitive to CIL in a chemotactic input-dependent manner and it is proposed that this intricate interplay may enhance the spread of loose cell ensembles in pathophysiological conditions such as cancer, and possibly other physiological settings.
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Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
TL;DR: Identifying nodes shared in metastasis and therapy resistance signalling networks should offer new opportunities to improve anticancer therapy beyond current strategies, to eliminate both nodular lesions and cells in metastatic transit.
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Profiling Functional and Biochemical Phenotypes of Circulating Tumor Cells Using a Two-Dimensional Sorting Device.
Mahla Poudineh,Mahmoud Labib,Sharif Uddin Ahmed,L. N. Matthew Nguyen,Leyla Kermanshah,Reza M. Mohamadi,Edward H. Sargent,Shana O. Kelley +7 more
TL;DR: A new microfluidic approach is described that profiles, along two independent phenotypic axes, the behavior of heterogeneous cell subpopulations and finds a strong correlation between the surface expression and migration potential of CTCs present in blood from mice with xenografted tumors.
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Machine-Learning-Driven Surface-Enhanced Raman Scattering Optophysiology Reveals Multiplexed Metabolite Gradients Near Cells
Félix Lussier,Dimitris Missirlis,Dimitris Missirlis,Joachim P. Spatz,Joachim P. Spatz,Jean-Francois Masson +5 more
TL;DR: The development and application of a machine learning approach in combination with a surface-enhanced Raman spectroscopy (SERS) nanoprobe to measure simultaneously the gradients of at least eight metabolites in vitro near different cell lines is reported, shining light on the implication of extracellular ATP within the cancer local environment.
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CTL- vs Treg lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma.
Jinyan Liu,Feng Li,Liping Wang,Xinfeng Chen,Dan Wang,Ling Cao,Yu Ping,Song Zhao,Bing Li,Stephen H. Thorne,Bin Zhang,Pawel Kalinski,Yi Zhang +12 more
TL;DR: The data showed that CCL4 and CCL20 recruit functionally different T lymphocyte subsets into oesophageal carcinoma, indicating CCL 4 and Ccl20 are potential predictors of ESCC patients’ survival.
References
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,Alison Stopeck,Jeri Matera,M. Craig Miller,James M. Reuben,Gerald V. Doyle,W. Jeffrey Allard,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
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