Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Lung-Derived Factors Mediate Breast Cancer Cell Migration through CD44 Receptor-Ligand Interactions in a Novel Ex Vivo System for Analysis of Organ-Specific Soluble Proteins
Jenny E. Chu,Jenny E. Chu,Ying Xia,Benjamin Chin-Yee,David Goodale,Alysha K. Croker,Alysha K. Croker,Alison L. Allan +7 more
TL;DR: The data suggest that interactions between CD44(+) breast cancer cells and soluble factors present in the lung microenvironment may play an important role in determining organotropic metastatic behavior.
Journal ArticleDOI
Inflammatory events during murine squamous cell carcinoma development.
Thaís Helena Gasparoto,Carine Ervolino de Oliveira,Luisa Thomazini de Freitas,Claudia Ramos Pinheiro,Rodrigo Nalio Ramos,André Luis Porto da Silva,Gustavo Pompermaier Garlet,João Santana da Silva,Ana Paula Campanelli +8 more
TL;DR: The results indicate an imbalance of inflammatory mediators in precancerous SCC caused by neutrophils and macrophages and culminating in pro-tumour local tissue alterations.
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PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena
Shannon K. Hughes,Madeleine J. Oudin,Jenny Tadros,Jason R. Neil,Amanda M. Del Rosario,Brian A. Joughin,Laila Ritsma,Jeff Wyckoff,Eliza Vasile,Robert J. Eddy,Ulrike Philippar,Alisha Lussiez,John S. Condeelis,Jacco van Rheenen,Forest M. White,Douglas A. Lauffenburger,Frank B. Gertler +16 more
TL;DR: The actin-binding protein Mena regulates RTK signaling after growth factor stimulation in tumor cells by a novel mechanism and the alternatively spliced MenaINV isoform disrupts this attenuation to drive sensitivity to growth factors, resistance to targeted inhibitors, and ultimately tumor invasion and metastasis.
Journal ArticleDOI
A Dynamic Model of Chemoattractant-Induced Cell Migration
TL;DR: A cell-migration model that facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time is developed and verified the correctness of the model using migrating leukemia cancer Jurkat cells.
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Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways
TL;DR: The current understanding of common dissemination pathways for tumors is reviewed to understand the complexities of metastasis and guide the design of new therapies that halt dissemination.
References
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