Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Markov Chain Modeling of the End-to-End Molecular Communication System Using Ligand Receiver
TL;DR: In this paper , an end-to-end biochemical communication modeling of an MC system is presented, where the transmitter is assumed to be a point source, and the receiver is embedded with finite ligand receptors.
DissertationDOI
Heterogeneous impact of hypoxia on cellular radiation sensitivity of three squamous cell carcinoma lines
Journal ArticleDOI
Quantifying the Morphology and Mechanisms of Cancer Progression in 3D In-Vitro Environments: Integrating Experiments and Multiscale Models
TL;DR: In this paper , an integrated experimental-computational framework for the quantification of the morphological characteristics and the mechanistic modelling of cancer progression in 3D environments is presented.
Book ChapterDOI
Dynamics of Gradient Sensing and Chemotaxis
TL;DR: A number of strategies used by cells that allow them to perform these various tasks successfully are reviewed.
References
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
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