Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cell migration in microengineered tumor environments
TL;DR: Key findings in cancer cell migration under the influence of the physical environment, which is systematically controlled by microengineering technology, are introduced, followed by multi-cues of physico-chemical factors, which represent the complexity of the tumor environment.
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Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling.
Steven G. Allen,Yu Chih Chen,Julie M. Madden,Chelsea Fournier,Megan Altemus,Ayse B. Hiziroglu,Yu Heng Cheng,Zhi Fen Wu,Liwei Bao,Joel A. Yates,Euisik Yoon,Sofia D. Merajver +11 more
TL;DR: It is determined that interleukins −6, −8, and −10 within the MCM are sufficient to stimulate this enhanced IBC migration effect, and that the known metastatic oncogene, RhoC GTPase, is necessary for the enhanced migration response.
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Different migration patterns of sea urchin and mouse sperm revealed by a microfluidic chemotaxis device.
TL;DR: In this article, the authors quantitatively assessed sea urchin and mouse sperm chemotaxis using a recently developed microfluidic model and high-speed imaging, and revealed a biological insight that chemotactic up a progesterone gradient may not be a universal strategy for mammalian sperm to reach eggs.
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Gβγ pathways in cell polarity and migration linked to oncogenic GPCR signaling: potential relevance in tumor microenvironment
José Vázquez-Prado,Ismael Bracho-Valdés,Rodolfo Daniel Cervantes-Villagrana,Guadalupe Reyes-Cruz +3 more
TL;DR: Emerging paradigms of Gβγ signaling in cancer are discussed, which are essential for chemotactic cell migration and represent novel opportunities to develop pathway-specific pharmacologic treatments.
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Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment
Sharon Wei Ling Lee,Sharon Wei Ling Lee,Sharon Wei Ling Lee,R J Seager,Felix Litvak,Fabian Spill,Fabian Spill,Fabian Spill,Je Lin Sieow,Hweixian Leong Penny,Dillip Kumar,Alrina Shin Min Tan,Siew Cheng Wong,Siew Cheng Wong,Giulia Adriani,Muhammad H. Zaman,Muhammad H. Zaman,Roger D. Kamm +17 more
TL;DR: A three-dimensional microfluidic-based model with tumor cells and macrophages is developed to study how IF affects macrophage migration and its potential contribution to cancer invasion and demonstrates the utility of an integrated in silico and 3D in vitro approach to aid the design of tumor-associatedmacrophage-based immunotherapeutic strategies.
References
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