Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Journal ArticleDOI
An indirect electric field-induced control in directional migration of rat mesenchymal stem cells
TL;DR: Indirect E-field therapy proved as tentative tool for controlled cell movement and healing for rat mesenchymal stem cell migration and wound closure.
Posted Content
From a discrete model of chemotaxis with volume-filling to a generalised Patlak-Keller-Segel model
TL;DR: In this article, the authors present a discrete model of chemotaxis whereby cells responding to a chemoattractant are seen as individual agents whose movement is described through a set of rules that result in a biased random walk.
Posted Content
Controlled dynamics and number fluctuations with two strategies for quorum sensing
TL;DR: The results are expected to shed light on how molecular regulation of chemotactic circuits can determine large-scale behavior of cell colonies and tissues through emergent properties that result from a subtle interplay between nonequilibrium fluctuations and long-range interactions that are constrained by exact symmetries.
Book ChapterDOI
Gradient Biomaterials and Their Impact on Cell Migration
TL;DR: In this chapter, the gradients existing in vivo and their influences on cell migration are firstly described and the impact of gradient biomaterials on cell responses is discussed, highlighting their potential application in regenerative medicine.
Journal ArticleDOI
Investigating Optimal Time Step Intervals of Imaging for Data Quality through a Novel Fully-Automated Cell Tracking Approach
TL;DR: A novel approach where the quality of data acquisition could help improve the accuracy of cell tracking algorithms and vice-versa, and establishes that there exist certain relationships between the tracking accuracy and the time step interval associated with experimental microscope data acquisition.
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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