Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Establishment of a scalable microfluidic assay for characterization of population‐based neutrophil chemotaxis
TL;DR: Compared to transwell assays, microfluidic approaches could offer several advantages, including precis e control of defined chemokine gradients in space and time, automated quantitative analysis of chemotaxis, and high throughput.
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Precision biomaterials in cancer theranostics and modelling
TL;DR: In this article , the authors discuss the latest advances in the field of precision biomaterials in cancer research, which are expected to revolutionize disease management, focusing on their uses for cancer modelling, detection, and therapeutic applications.
Journal ArticleDOI
SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy
Chiara De-Colle,David Mönnich,David Mönnich,Stefan Welz,S. Boeke,Bence Sipos,Falko Fend,Paul-Stefan Mauz,Inge Tinhofer,Inge Tinhofer,Volker Budach,Volker Budach,Jehad Abu Jawad,Jehad Abu Jawad,Martin Stuschke,Martin Stuschke,Panagiotis Balermpas,Panagiotis Balermpas,Claus Rödel,Claus Rödel,Anca-Ligia Grosu,Anca-Ligia Grosu,Amir Abdollahi,Jürgen Debus,Christine Bayer,Claus Belka,Claus Belka,Steffi Pigorsch,Steffi Pigorsch,Stephanie E. Combs,Stephanie E. Combs,Fabian Lohaus,Annett Linge,Mechthild Krause,Michael Baumann,Daniel Zips,Daniel Zips,Apostolos Menegakis +37 more
TL;DR: Outcome after postoperative radiochemotherapy in head and neck cancer is unsatisfactory and the chemokine axis SDF-1/CXCR4 as biomarker for patients stratification is proposed.
Book ChapterDOI
Breast Cancer Metastasis.
TL;DR: In this paper, the authors discuss recent discovery and advances in the field of breast cancer metastasis research, and discuss the major players and molecules in this process, which is mainly attributed to the complexity of metastatic process.
Journal ArticleDOI
Three-Dimensional in Vitro Model to Study Osteobiology and Osteopathology.
TL;DR: It is proposed that one can at minimum study the interaction between osteoblasts (bone formation) and osteoclasts ( bone degradation) in a three dimensional (3D) “bioreactor” and the 3D system holds promise for further studies of cancer dormancy, hormone, and cytokine effects and matrix manipulation.
References
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Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
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Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
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