Chemotaxis in cancer
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.Abstract:
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.read more
Citations
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Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.
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Classifying collective cancer cell invasion
TL;DR: A framework for addressing potential mechanisms, experimental strategies and technical challenges to study collective cancer cell invasion is proposed.
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Ioannis K. Zervantonakis,Shannon K. Hughes-Alford,Joseph L. Charest,John S. Condeelis,Frank B. Gertler,Roger D. Kamm +5 more
TL;DR: Evidence is provided that the endothelium poses a barrier to tumor cell intravasation that can be regulated by factors present in the tumor microenvironment.
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Differential macrophage programming in the tumor microenvironment.
TL;DR: Targeting molecular pathways regulating TAM polarization holds great promise for anticancer therapy.
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Crossing the endothelial barrier during metastasis
TL;DR: How cancer cells cross the endothelial barrier during extravasation is described and how different receptors, signalling pathways and circulating cells such as leukocytes and platelets contribute to this process are described.
References
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TL;DR: Recent developments in actin biology that particularly affect structures at the leading edge of the cell, including the structure of actin branches, the multiple pathways that lead to cytoskeleton assembly and disassembly, and the role of blebs are summarized.
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Rizwan Farooqui,Gabriel Fenteany +1 more
TL;DR: It is reported here for the first time that cells behind the margin of wounded MDCK cell monolayers, even hundreds of microns from the edge, extend `cryptic' lamellipodia against the substratum beneath cells in front of them, toward the wound, as determined by confocal, two-photon and transmission electron microscopy.
Journal Article
CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers
Ilona Kryczek,Andrzej Lange,Peter Mottram,Xavier Alvarez,Pui Cheng,Melina Hogan,Lieve Moons,Shuang Wei,Linhua Zou,Véronique Machelon,Dominique Emilie,Margarita Terrassa,Andrew A. Lackner,Tyler J. Curiel,Peter Carmeliet,Weiping Zou +15 more
TL;DR: It is shown that hypoxia synchronously induces tumor CXCL12 and VEGF production and form a synergistic angiogenic axis in vivo, which will be a novel efficient antiangiogenesis strategy to treat cancer.
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Chemokines and the molecular basis of cancer metastasis.
TL;DR: Since the work of Paget more than 100 years ago, pathologists have recognized that the movement of cancer cells is not random and that different types of cancer have different destinations.
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Matrix metalloproteinases in tumor invasion: role for cell migration.
TL;DR: Cell surface localization and activation of MMP is essential for cells to migrate, through rearrangement of extracellular matrix (ECM) to suit cell migration.
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