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Open AccessJournal ArticleDOI

Chemotaxis in cancer

Evanthia T. Roussos, +2 more
- 01 Aug 2011 - 
- Vol. 11, Iss: 8, pp 573-587
TLDR
This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulateChemotaxis in tumours and how chemtaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread.
Abstract: 
Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

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Posted ContentDOI

Chemotaxis and topotaxis add vectorially for amoeboid cell migration

Joeri A. J. Wondergem, +7 more
- 14 Aug 2019 - 
TL;DR: It is argued that topotaxis must be conserved during chemotaxis, as it is an emergent property of both the asymmetric properties of the pillar field and the inherent stochasticity of (biased) amoeboid migration.
Journal ArticleDOI

TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis.

Francesca Ferranti, +10 more
- 01 Oct 2013 - 
TL;DR: The ability of a culture medium added with 10% egg albumen (EW, Egg White) to modulate seminoma cell phenotype and behaviour is investigated, by ensuring a proper set of morphogenetic signals.
Journal ArticleDOI

Novel therapeutic agents for the treatment of gastroenteropancreatic neuroendocrine tumors.

Marianne Pavel, +1 more
- 01 Nov 2011 - 
TL;DR: An overview on novel drugs, focus on the impact of recently approved drugs on the management of NET disease, and outline future perspectives are provided.
Journal ArticleDOI

Influence of transcriptional variants on metastasis.

Joice de Faria Poloni, +1 more
- 24 Jul 2018 - 
TL;DR: How transcriptional variants contribute to metastatic competence and how targeting specific isoforms may be a promising therapeutic strategy are described are described.
Book ChapterDOI

Seeing Is Believing: Noninvasive Microscopic Imaging Modalities for Tissue Engineering and Regenerative Medicine

Nuno Neto, +2 more
References
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Journal ArticleDOI

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Jean Paul Thiery, +5 more
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TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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Dmitry I. Gabrilovich, +1 more
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TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
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Anja Müller, +13 more
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TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Tyler J. Curiel, +20 more
- 22 Aug 2004 - 
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
Journal ArticleDOI

Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer

Massimo Cristofanilli, +10 more
- 19 Aug 2004 - 
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
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What part of chemotaxis in cancer has not been studied yet?

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