Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
Chih-Jung Chang,Chuan-Sheng Lin,Chia-Chen Lu,Jan Martel,Yun-Fei Ko,David M. Ojcius,Shun-Fu Tseng,Tsung-Ru Wu,Yi-Yuan Margaret Chen,John D. Young,Hsin-Chih Lai +10 more
TLDR
The results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.Abstract:
Obesity is associated with low-grade chronic inflammation and intestinal dysbiosis. Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative anti-diabetic effects. Here, we show that a water extract of Ganoderma lucidum mycelium (WEGL) reduces body weight, inflammation and insulin resistance in mice fed a high-fat diet (HFD). Our data indicate that WEGL not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios and endotoxin-bearing Proteobacteria levels-but also maintains intestinal barrier integrity and reduces metabolic endotoxemia. The anti-obesity and microbiota-modulating effects are transmissible via horizontal faeces transfer from WEGL-treated mice to HFD-fed mice. We further show that high molecular weight polysaccharides (>300 kDa) isolated from the WEGL extract produce similar anti-obesity and microbiota-modulating effects. Our results indicate that G. lucidum and its high molecular weight polysaccharides may be used as prebiotic agents to prevent gut dysbiosis and obesity-related metabolic disorders in obese individuals.read more
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Gut microbiota dysbiosis contributes to the development of hypertension.
Jing-Jing Li,Jing-Jing Li,Fangqing Zhao,Yidan Wang,Junru Chen,Jie Tao,Gang Tian,Shouling Wu,Wenbin Liu,Qinghua Cui,Bin Geng,Weili Zhang,Ryan Weldon,Kelda Auguste,Lei Yang,Xiaoyan Liu,Li Chen,Li Chen,Li Chen,Xinchun Yang,Baoli Zhu,Baoli Zhu,Jun Cai +22 more
TL;DR: A novel causal role of aberrant gut microbiota in contributing to the pathogenesis of hypertension is described and the significance of early intervention for pre-hypertension was emphasized.
Journal ArticleDOI
Akkermansia muciniphila and its role in regulating host functions.
TL;DR: The aims of this review are to summarize the existing data on the intestinal distribution of A. muciniphila, to provide insight into its ecology and its role in founding microbial networks at the mucosal interface, as well as to discuss recent research on itsrole in regulating host functions that are disturbed in various diseases.
Journal ArticleDOI
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment.
TL;DR: Network pharmacology is a rational approach for TCM studies, and with the development of TCM research, powerful and comprehensive TCM databases have emerged but need further improvements.
Journal ArticleDOI
Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis.
Tsung-Ru Wu,Chuan-Sheng Lin,Chih-Jung Chang,Tzu-Lung Lin,Jan Martel,Yun-Fei Ko,David M. Ojcius,Chia-Chen Lu,John Ding-E Young,Hsin-Chih Lai +9 more
TL;DR: HSM polysaccharides and the gut bacterium P. goldsteinii represent novel prebiotics and probiotics that may be used to treat obesity and type 2 diabetes.
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