Akkermansia muciniphila and its role in regulating host functions.
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TLDR
The aims of this review are to summarize the existing data on the intestinal distribution of A. muciniphila, to provide insight into its ecology and its role in founding microbial networks at the mucosal interface, as well as to discuss recent research on itsrole in regulating host functions that are disturbed in various diseases.About:
This article is published in Microbial Pathogenesis.The article was published on 2017-05-01 and is currently open access. It has received 635 citations till now. The article focuses on the topics: Akkermansia muciniphila & Akkermansia.read more
Citations
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Introduction to the human gut microbiota
Elizabeth Thursby,Nathalie Juge +1 more
TL;DR: This review summarises the current understanding of the development and composition of the human GI microbiota, and its impact on gut integrity and host health, underlying the need for mechanistic studies focusing on host–microbe interactions.
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Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.
Egle Cekanaviciute,Bryan B. Yoo,Tessel F. Runia,Justine W. Debelius,Sneha Singh,Charlotte A. Nelson,Rachel Kanner,Yadira Bencosme,Yun Kyung Lee,Stephen L. Hauser,Elizabeth Crabtree-Hartman,Ilana Katz Sand,Mar Gacias,Yungjiao Zhu,Patrizia Casaccia,Patrizia Casaccia,Bruce A.C. Cree,Rob Knight,Sarkis K. Mazmanian,Sergio E. Baranzini +19 more
TL;DR: The results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.
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An insight into gut microbiota and its functionalities.
Atanu Adak,Mojibur R. Khan +1 more
TL;DR: An in-depth understanding of the functioning of gut microbiota has led to some very exciting developments in therapeutics, such as prebiotics, probiotics, drugs and faecal transplantation leading to improved health.
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Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease
TL;DR: The molecular underpinnings of these polysaccharide degradation processes, their impact on human health, and how the authors can manipulate them through the use of prebiotics are summarized.
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Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
Adam B. Roberts,Adam B. Roberts,Xiaodong Gu,Xiaodong Gu,Jennifer A. Buffa,Jennifer A. Buffa,Alex G Hurd,Alex G Hurd,Alex G Hurd,Zeneng Wang,Zeneng Wang,Weifei Zhu,Weifei Zhu,Nilaksh Gupta,Nilaksh Gupta,Sarah M. Skye,Sarah M. Skye,David B. Cody,Bruce S. Levison,William T. Barrington,Matthew W Russell,Matthew W Russell,Jodie Michelle Reed,Ashraf Duzan,Ashraf Duzan,Jennifer M. Lang,Xiaoming Fu,Xiaoming Fu,Lin Li,Lin Li,Alex J Myers,Alex J Myers,Suguna Rachakonda,Suguna Rachakonda,Joseph A. DiDonato,Joseph A. DiDonato,J. Mark Brown,J. Mark Brown,Valentin Gogonea,Valentin Gogonea,Valentin Gogonea,Aldons J. Lusis,Jose C. Garcia-Garcia,Stanley L. Hazen,Stanley L. Hazen +44 more
TL;DR: These studies reveal that mechanism-based inhibition of gut microbial TMA and TMAO production reduces thrombosis potential, a critical adverse complication in heart disease, and offer a generalizable approach for the selective nonlethal targeting of Gut microbial enzymes linked to host disease limiting systemic exposure of the inhibitor in the host.
References
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TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
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A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
Journal ArticleDOI
Phylogenetic structure of the prokaryotic domain: The primary kingdoms
Carl R. Woese,George E. Fox +1 more
TL;DR: A phylogenetic analysis based upon ribosomal RNA sequence characterization reveals that living systems represent one of three aboriginal lines of descent: the eubacteria, comprising all typical bacteria, the archaebacteria, and the urkaryotes, now represented in the cytoplasmic component of eukaryotic cells.
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