Genome-wide association of major depression: Description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
Dorret I. Boomsma,Gonneke Willemsen,Patrick F. Sullivan,Peter Heutink,Piet Meijer,David Sondervan,Cornelis Kluft,Guus Smit,Willem A. Nolen,Frans G. Zitman,Johannes H. Smit,Witte J.G. Hoogendijk,Richard van Dyck,Eco J. C. de Geus,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx +15 more
TLDR
The large-scale nationwide biological sample collection in Dutch twin families from the Netherlands Twin Register (NTR) and in participants in the Netherlands Study of Depression and Anxiety (NESDA) is described.Abstract:
To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly review linkage studies of MDD and then describe the large-scale nationwide biological sample collection in Dutch twin families from the Netherlands Twin Register (NTR) and in participants in the Netherlands Study of Depression and Anxiety (NESDA). Within these studies, 1862 participants with a diagnosis of MDD and 1857 controls at low liability for MDD have been selected for genome-wide genotyping by the US Foundation for the National Institutes of Health Genetic Association Information Network. Stage 1 genome-wide association results are scheduled to be accessible before the end of 2007. Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007.read more
Citations
More filters
Journal ArticleDOI
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Yurii S. Aulchenko,Samuli Ripatti,Ida Lindqvist,Dorret I. Boomsma,Iris M. Heid,Peter P. Pramstaller,Brenda W.J.H. Penninx,A. Cecile J.W. Janssens,James F. Wilson,Tim D. Spector,Nicholas G. Martin,Nancy L. Pedersen,Kirsten Ohm Kyvik,Jaakko Kaprio,Albert Hofman,Nelson B. Freimer,Marjo-Riitta Järvelin,Ulf Gyllensten,Harry Campbell,Igor Rudan,Åsa Johansson,Fabio Marroni,Caroline Hayward,Veronique Vitart,Inger Jonasson,Cristian Pattaro,Alan F. Wright,Nicholas D. Hastie,Irene Pichler,Andrew A. Hicks,Mario Falchi,Gonneke Willemsen,Jouke-Jan Hottenga,Eco J. C. de Geus,Grant W. Montgomery,John Whitfield,Patrik K. E. Magnusson,Juha Saharinen,Markus Perola,Kaisa Silander,Aaron Isaacs,Eric J.G. Sijbrands,André G. Uitterlinden,Jacqueline C.M. Witteman,Ben A. Oostra,Paul Elliott,Aimo Ruokonen,Chiara Sabatti,Christian Gieger,Thomas Meitinger,Florian Kronenberg,Angela Döring,H-Erich Wichmann,Johannes H. Smit,Mark I. McCarthy,Cornelia M. van Duijn,Leena Peltonen +56 more
TL;DR: The first GWA analysis of loci affecting total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform establishes 22 loci associated with serum lipid levels at genome-wide significance level.
Journal ArticleDOI
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods.
Brenda W.J.H. Penninx,Aartjan T.F. Beekman,Jan Smit,Frans G. Zitman,Willem A. Nolen,Philip Spinhoven,Pim Cuijpers,de Peter Jong,H.W.J. van Marwijk,Willem J J Assendelft,van der Klaas Meer,Peter F. M. Verhaak,Michel Wensing,R. de Graaf,Witte J.G. Hoogendijk,Johan Ormel,R. van Dyck +16 more
TL;DR: The Netherlands Study of Depression and Anxiety is a multi‐site naturalistic cohort study to describe the long‐term course and consequences of depressive and anxiety disorders and to integrate biological and psychosocial research paradigms within an epidemiological approach.
Identification of seven loci affecting mean telomere length and their association with disease
Veryan Codd,Christopher P. Nelson,Eva Albrecht,Massimo Mangino,Joris Deelen,Jessica L. Buxton,Jouke-Jan Hottenga,Krista Fischer,Tõnu Esko,Ida Surakka,Linda Broer,Dale R. Nyholt,Irene Mateo Leach,Perttu Salo,Sara Hägg,Mary K. Matthews,Jutta Palmen,Giuseppe Danilo Norata,Paul F. O'Reilly,Danish Saleheen,Najaf Amin,Anthony J. Balmforth,Marian Beekman,Rudolf A. de Boer,Stefan Böhringer,Peter S. Braund,Paul Burton,Anton J. M. de Craen,Matthew Denniff,Yanbin Dong,Konstantinos Douroudis,Elena Dubinina,Johan G. Eriksson,Katia Garlaschelli,Dehuang Guo,Anna-Liisa Hartikainen,Anjali K. Henders,Jeanine J. Houwing-Duistermaat,Laura Kananen,Lennart C. Karssen,Johannes Kettunen,Norman Klopp,Vasiliki Lagou,Elisabeth M. van Leeuwen,Pamela A. F. Madden,Reedik Maegi,Patrik K. E. Magnusson,Satu Männistö,Mark I. McCarthy,Sarah E. Medland,Evelin Mihailov,Grant W. Montgomery,Ben A. Oostra,Aarno Palotie,Annette Peters,Helen Pollard,Anneli Pouta,Inga Prokopenko,Samuli Ripatti,Veikko Salomaa,H. Eka D. Suchiman,Ana M. Valdes,Niek Verweij,Ana Viñuela,Xiaoling Wang,H-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,Margaret J. Wright,Kai Xia,Xiangjun Xiao,Dirk J. van Veldhuisen,Alberico L. Catapano,Martin D. Tobin,Alistair S. Hall,Alexandra I. F. Blakemore,Wiek H. van Gilst,Haidong Zhu,Jeanette Erdmann,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Philippa J. Talmud,Nancy L. Pedersen,Markus Perola,Willem H. Ouwehand,Jaakko Kaprio,Nicholas G. Martin,Cornelia M. van Duijn,Iris Hovatta,Christian Gieger,Andres Metspalu,Dorret I. Boomsma,Marjo-Riitta Järvelin,P. Eline Slagboom,John R Thompson,Tim D. Spector,Pim van der Harst,Nilesh J. Samani +98 more
TL;DR: In this article, a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals was carried out to identify seven loci, including five new loci associated with mean leukocyte telomere length (LTL).
Journal Article
Identification of common varants associated with humanhippocampal and intracranial volumes
Jason L. Stein,Richard Barteček +1 more
TL;DR: A genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium are reported and a suggestive association with total brain volume is identified.
Journal ArticleDOI
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Cathy E. Elks,John R. B. Perry,Patrick Sulem,Daniel I. Chasman,Nora Franceschini,Chunyan He,Kathryn L. Lunetta,Kathryn L. Lunetta,Jenny A. Visser,Enda M. Byrne,Enda M. Byrne,Diana L. Cousminer,Daniel F. Gudbjartsson,Tõnu Esko,Bjarke Feenstra,Jouke-Jan Hottenga,Daniel L. Koller,Zoltán Kutalik,Zoltán Kutalik,Peng Lin,Massimo Mangino,Mara Marongiu,Patrick F. McArdle,Albert V. Smith,Lisette Stolk,Sophie H. Van Wingerden,Jing Hua Zhao,Eva Albrecht,Tanguy Corre,Erik Ingelsson,Caroline Hayward,Patrik K. E. Magnusson,Erin N. Smith,Erin N. Smith,S. Ulivi,Nicole M. Warrington,Lina Zgaga,Helen Alavere,Najaf Amin,Thor Aspelund,Stefania Bandinelli,Inês Barroso,Gerald S. Berenson,Sven Bergmann,Sven Bergmann,Hannah Blackburn,Eric Boerwinkle,Julie E. Buring,Fabio Busonero,Harry Campbell,Stephen J. Chanock,Wei Chen,Marilyn C. Cornelis,David Couper,Andrea D. Coviello,Pio D'Adamo,Ulf de Faire,Eco J. C. de Geus,Panos Deloukas,Angela Döring,George Davey Smith,Douglas F. Easton,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Aaron R. Folsom,Tatiana Foroud,Melissa E. Garcia,Paolo Gasparini,Frank Geller,Christian Gieger,Vilmundur Gudnason,Per Hall,Susan E. Hankinson,Liana Ferreli,Andrew C. Heath,Dena G. Hernandez,Albert Hofman,Frank B. Hu,Thomas Illig,Marjo-Riitta Järvelin,Andrew D. Johnson,David Karasik,Kay-Tee Khaw,Douglas P. Kiel,Tuomas O. Kilpelänen,Ivana Kolcic,Peter Kraft,Lenore J. Launer,Joop S.E. Laven,Shengxu Li,Jianjun Liu,Daniel Levy,Daniel Levy,Nicholas G. Martin,Wendy L. McArdle,Mads Melbye,Vincent Mooser,Jeffrey C. Murray,Sarah S. Murray,Sarah S. Murray,Mike A. Nalls,Pau Navarro,Mari Nelis,Andy R Ness,Kate Northstone,Ben A. Oostra,Munro Peacock,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alex Parker,Nancy L. Pedersen,Leena Peltonen,Craig E. Pennell,Paul D.P. Pharoah,Ozren Polasek,Andrew S. Plump,Anneli Pouta,Eleonora Porcu,Thorunn Rafnar,John P. Rice,Susan M. Ring,Fernando Rivadeneira,Igor Rudan,Igor Rudan,Cinzia Sala,Veikko Salomaa,Serena Sanna,David Schlessinger,Nicholas J. Schork,Nicholas J. Schork,Angelo Scuteri,Ayellet V. Segrè,Ayellet V. Segrè,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Sathanur R. Srinivasan,David P. Strachan,Mar Liis Tammesoo,Emmi Tikkanen,Emmi Tikkanen,Daniela Toniolo,Kim Tsui,Laufey Tryggvadottir,Tyrer Jp,Manuela Uda,Rob M. van Dam,Rob M. van Dam,Joyce B. J. van Meurs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,Michael N. Weedon,H.-Erich Wichmann,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Lauren Young,Guangju Zhai,Wei Vivian Zhuang,Laura J. Bierut,Dorret I. Boomsma,Heather A. Boyd,Laura Crisponi,Ellen W. Demerath,Cornelia M. van Duijn,Michael J. Econs,Tamara B. Harris,David J. Hunter,David J. Hunter,Ruth J. F. Loos,Andres Metspalu,Grant W. Montgomery,Paul M. Ridker,Tim D. Spector,Elizabeth A. Streeten,Kari Stefansson,Kari Stefansson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,Elisabeth Widen,Joanne M. Murabito,Joanne M. Murabito,Ken K. Ong,Ken K. Ong,Anna Murray +196 more
TL;DR: A meta-analysis of 32 genome-wide association studies in 87,802 women of European descent found 30 new menarche loci and found suggestive evidence for a further 10 loci, including four previously associated with body mass index and three in or near genes implicated in hormonal regulation.
References
More filters
Journal ArticleDOI
An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
An inventory for measuring clinical anxiety: psychometric properties.
TL;DR: Un nouvel inventaire auto-administre destine a mesurer l'anxiete pathologique, le «Beck Anxiety Cheklist» (BAI) est decrit, evalue et compare au «Hamilton Anxiety Rating Scale» (test avec lequel des correlations moderees sont trouvees).
Journal ArticleDOI
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Paul Burton,David Clayton,Lon R. Cardon,Nicholas John Craddock,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Nilesh J. Samani,John A. Todd,Peter Donnelly,Jeffrey C. Barrett,Dan Davison,Doug Easton,David M. Evans,H. T. Leung,Jonathan Marchini,Andrew P. Morris,Chris C. A. Spencer,Martin D. Tobin,Antony P. Attwood,James P. Boorman,Barbara Cant,Ursula Everson,Judith M. Hussey,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Elizabeth Meech,Sarah Nutland,Christopher Prowse,Helen Stevens,Niall C. Taylor,Graham R. Walters,Neil Walker,Nicholas A. Watkins,Thilo Winzer,Richard Jones,Wendy L. McArdle,Susan M. Ring,David P. Strachan,Marcus Pembrey,Gerome Breen,David St Clair,Sian Caesar,Katherine Gordon-Smith,Lisa Jones,Christine Fraser,Elaine K. Green,Detelina Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskvina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGuffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,John R. Thompson,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Alastair Forbes,Cathryn M. Lewis,Clive M. Onnie,Natalie J. Prescott,Jeremy D. Sanderson,Christopher G. Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,John Webster,Morris J. Brown,G. Mark Lathrop,John M. C. Connell,Anna F. Dominiczak,Carolina A. Braga Marcano,Beverley Burke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Patricia B. Munroe,Stephen Newhouse,Abiodun Onipinla,Chris Wallace,Mingzhan Xue,Mark J. Caulfield,Martin Farrall,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,David B. Dunger,Barry Widmer,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Beverley M. Shields,Michael N. Weedon,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Kate S. Elliott,Christopher J. Groves,Cecilia M. Lindgren,Nigel W. Rayner,Nicholas J. Timpson,Eleftheria Zeggini,Melanie J. Newport,Giorgio Sirugo,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Linda A. Bradbury,C Farrar,J J Pointon,Paul Wordsworth,Matthew A. Brown,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C. L. Gough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Maria Ban,An Goris,Stephen Sawcer,Alastair Compston,David J. Conway,Muminatou Jallow,Kirk A. Rockett,Suzannah Bumpstead,Amy Chaney,Kate Downes,Mohammed J. R. Ghori,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Andrew Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajah,Pamela Whittaker,Claire Widden,David Withers,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingileif B. Hallgrímsdóttir,Bryan Howie,Zhan Su,Yik Ying Teo,Damjan Vukcevic,David Bentley,A Compston +195 more
TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Related Papers (5)
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods.
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
A mega-analysis of genome-wide association studies for major depressive disorder
Stephan Ripke,Naomi R. Wray,Cathryn M. Lewis,Steven P. Hamilton,Myrna M. Weissman,Gerome Breen,Enda M. Byrne,Douglas Blackwood,Dorret I. Boomsma,Sven Cichon,Andrew C. Heath,Florian Holsboer,Susanne Lucae,Pamela A. F. Madden,Nicholas G. Martin,Peter McGuffin,Pierandrea Muglia,Markus M. Noethen,Brenda P Penninx,Michele L. Pergadia,James B. Potash,Marcella Rietschel,Danyu Lin,Bertram Müller-Myhsok,Jianxin Shi,Stacy Steinberg,Hans J. Grabe,Paul Lichtenstein,Patrik K. E. Magnusson,Roy H. Perlis,Martin Preisig,Jordan W. Smoller,Kari Stefansson,Rudolf Uher,Zoltán Kutalik,Katherine E. Tansey,Alexander Teumer,Alexander Viktorin,Michael R. Barnes,Thomas Bettecken,Elisabeth B. Binder,René Breuer,Victor M. Castro,Susanne Churchill,William Coryell,Nicholas John Craddock,Ian W. Craig,Darina Czamara,Eco J. C. de Geus,Franziska Degenhardt,Anne Farmer,Maurizio Fava,Josef Frank,Vivian S. Gainer,Patience J. Gallagher,Scott D. Gordon,Sergey Goryachev,Magdalena Gross,Michel Guipponi,Anjali K. Henders,Stefan Herms,Ian B. Hickie,Susanne Hoefels,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Dan V. Iosifescu,Marcus Ising,Ian Jones,Lisa Jones,Tzeng Jung-Ying,James A. Knowles,Isaac S. Kohane,Martin A. Kohli,Ania Korszun,Mikael Landén,William Lawson,Glyn Lewis,Donald J. MacIntyre,Wolfgang Maier,Manuel Mattheisen,Patrick J. McGrath,Andrew M. McIntosh,Alan W. McLean,Christel M. Middeldorp,Lefkos T. Middleton,G. M. Montgomery,Shawn N. Murphy,Matthias Nauck,Willem A. Nolen,Dale R. Nyholt,Michael Conlon O'Donovan,Hogni Oskarsson,Nancy L. Pedersen,William A. Scheftner,Andrea Schulz,Thomas G Schulze,Stanley I. Shyn,Engilbert Sigurdsson,Susan L. Slager,Johannes H. Smit,Hreinn Stefansson,Michael Steffens,Thorgeir E. Thorgeirsson,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Henry Völzke,Jeffrey B. Weilburg,Gonneke Willemsen,Frans G. Zitman,Benjamin M. Neale,Mark J. Daly,Douglas F. Levinson,Patrick F. Sullivan +115 more