The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods.
Brenda W.J.H. Penninx,Aartjan T.F. Beekman,Jan Smit,Frans G. Zitman,Willem A. Nolen,Philip Spinhoven,Pim Cuijpers,de Peter Jong,H.W.J. van Marwijk,Willem J J Assendelft,van der Klaas Meer,Peter F. M. Verhaak,Michel Wensing,R. de Graaf,Witte J.G. Hoogendijk,Johan Ormel,R. van Dyck +16 more
Reads0
Chats0
TLDR
The Netherlands Study of Depression and Anxiety is a multi‐site naturalistic cohort study to describe the long‐term course and consequences of depressive and anxiety disorders and to integrate biological and psychosocial research paradigms within an epidemiological approach.Abstract:
The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial research paradigms within an epidemiological approach in order to examine (interaction between) predictors of the long-term course and consequences. Its design is an eight-year longitudinal cohort study among 2981 participants aged 18 through 65 years. The sample consists of 1701 persons with a current (six-month recency) diagnosis of depression and/or anxiety disorder, 907 persons with life-time diagnoses or at risk because of a family history or subthreshold depressive or anxiety symptoms, and 373 healthy controls. Recruitment took place in the general population, in general practices (through a three-stage screening procedure), and in mental health organizations in order to recruit persons reflecting various settings and developmental stages of psychopathology. During a four-hour baseline assessment including written questionnaires, interviews, a medical examination, a cognitive computer task and collection of blood and saliva samples, extensive information was gathered about key (mental) health outcomes and demographic, psychosocial, clinical, biological and genetic determinants. Detailed assessments will be repeated after one, two, four and eight years of follow-up. The findings of NESDA are expected to provide more detailed insight into (predictors of) the long-term course of depressive and anxiety disorders in adults. Besides its scientific relevance, this may contribute to more effective prevention and treatment of depressive and anxiety disorders.read more
Citations
More filters
Journal ArticleDOI
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Aysu Okbay,Bart M. L. Baselmans,Jan-Emmanuel De Neve,Patrick Turley,Michel G. Nivard,Mark Alan Fontana,S. Fleur W. Meddens,S. Fleur W. Meddens,S. Fleur W. Meddens,Richard Karlsson Linnér,Richard Karlsson Linnér,Richard Karlsson Linnér,Cornelius A. Rietveld,Jaime Derringer,Jacob Gratten,James J. Lee,Jimmy Z. Liu,Ronald de Vlaming,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Jadwiga Buchwald,Alana Cavadino,Alexis C. Frazier-Wood,Nicholas A. Furlotte,Victoria Garfield,Marie Henrike Geisel,Juan R. González,Saskia Haitjema,Robert Karlsson,Sander W. van der Laan,Karl-Heinz Ladwig,Jari Lahti,Sven J. van der Lee,Penelope A. Lind,Tian Liu,Lindsay K. Matteson,Evelin Mihailov,Michael B. Miller,Camelia C. Minică,Ilja M. Nolte,Dennis O. Mook-Kanamori,Peter J. van der Most,Christopher Oldmeadow,Yong Qian,Olli T. Raitakari,Olli T. Raitakari,Rajesh Rawal,Anu Realo,Anu Realo,Rico Rueedi,Rico Rueedi,Börge Schmidt,Albert V. Smith,Evie Stergiakouli,Toshiko Tanaka,Kent D. Taylor,Gudmar Thorleifsson,Juho Wedenoja,Juergen Wellmann,Harm-Jan Westra,Sara M. Willems,Wei Zhao,Najaf Amin,Andrew Bakshi,Sven Bergmann,Sven Bergmann,Gyda Bjornsdottir,Patricia A. Boyle,Samantha Cherney,Simon R. Cox,Gail Davies,Oliver S. P. Davis,Jun Ding,Nese Direk,Peter Eibich,Peter Eibich,Rebecca T. Emeny,Ghazaleh Fatemifar,Jessica D. Faul,Luigi Ferrucci,Andreas J. Forstner,Christian Gieger,Richa Gupta,Tamara B. Harris,Juliette Harris,Elizabeth G. Holliday,Jouke-Jan Hottenga,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Marika Kaakinen,Marika Kaakinen,Eero Kajantie,Eero Kajantie,Ville Karhunen,Ivana Kolcic,Meena Kumari,Lenore J. Launer,Lude Franke,Ruifang Li-Gao,David C. Liewald,Marisa Koini,Anu Loukola,Pedro Marques-Vidal,Grant W. Montgomery,Miriam A. Mosing,Lavinia Paternoster,Alison Pattie,K. Petrovic,Laura Pulkki-Råback,Lydia Quaye,Katri Räikkönen,Igor Rudan,Rodney J. Scott,Jennifer A. Smith,Angelina R. Sutin,Angelina R. Sutin,Maciej Trzaskowski,Maciej Trzaskowski,Anna A. E. Vinkhuyzen,Lei Yu,Delilah Zabaneh,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Lars Bertram,Dorret I. Boomsma,Harold Snieder,Shun-Chiao Chang,Francesco Cucca,Ian J. Deary,Cornelia M. van Duijn,Johan G. Eriksson,Johan G. Eriksson,Ute Bültmann,Eco J. C. de Geus,Patrick J. F. Groenen,Vilmundur Gudnason,Torben Hansen,C.A. Hartman,Claire M. A. Haworth,Caroline Hayward,Andrew C. Heath,David A. Hinds,Elina Hyppönen,Elina Hyppönen,William G. Iacono,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Jaakko Kaprio,Sharon L.R. Kardia,Liisa Keltikangas-Järvinen,Peter Kraft,Laura D. Kubzansky,Terho Lehtimäki,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Andres Metspalu,Melinda Mills,Renée de Mutsert,Albertine J. Oldehinkel,Gerard Pasterkamp,Nancy L. Pedersen,Robert Plomin,Ozren Polasek,Christine Power,Stephen S. Rich,Frits R. Rosendaal,Hester M. den Ruijter,David Schlessinger,Helena Schmidt,Rauli Svento,Reinhold Schmidt,Behrooz Z. Alizadeh,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Tim D. Spector,John M. Starr,Kari Stefansson,Kari Stefansson,Andrew Steptoe,Antonio Terracciano,Antonio Terracciano,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,André G. Uitterlinden,Peter Vollenweider,Gert G. Wagner,Gert G. Wagner,Gert G. Wagner,David R. Weir,Jian Yang,Dalton Conley,George Davey Smith,Albert Hofman,Albert Hofman,Magnus Johannesson,David Laibson,Sarah E. Medland,Michelle N. Meyer,Michelle N. Meyer,Joseph K. Pickrell,Tõnu Esko,Robert F. Krueger,Jonathan P. Beauchamp,Philipp Koellinger,Philipp Koellinger,Philipp Koellinger,Daniel J. Benjamin,Meike Bartels,David Cesarini +216 more
TL;DR: In this paper, the authors conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n= 161,460), and neuroticism(n = 170,911).
Journal ArticleDOI
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,Kelly S. Benke,Lawrence F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,Christiaan de Leeuw,Niina Eklund,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Erik Ingelsson,Bo Jacobsson,Bo Jacobsson,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,Kati Kristiansson,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,George McMahon,Pedro Marques Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Christopher Oldmeadow,Katja Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,Helena Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,Antonio Terracciano,Matthijs J. H. M. van der Loos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Francesco Cucca,Mariza de Andrade,Philip L. De Jager,Jan-Emmanuel De Neve,Jan-Emmanuel De Neve,Ian J. Deary,George Dedoussis,Panos Deloukas,Maria Dimitriou,Guoný Eiríksdóttir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Juliette Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,Wolfgang Hoffmann,Adriaan Hofman,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,Antti Latvala,Lenore J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Pamela A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,Marco Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Sutapa Mukherjee,Dale R. Nyholt,Ben A. Oostra,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Patricia A. Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,Susan M. Ring,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,Beate St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,Frank J. A. van Rooij,David R. Van Wagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,Judith M. Vonk,Gérard Waeber,David R. Weir,H.-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Michelle N. Meyer,Danielle Posthuma,Danielle Posthuma,Roy Thurik,Nicholas J. Timpson,André G. Uitterlinden,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,David Cesarini,David Cesarini,Philipp Koellinger +230 more
TL;DR: In this article, a genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490 individuals, and three independent SNPs are genome wide significant (rs9320913, rs11584700, rs4851266).
Journal ArticleDOI
Whole brain resting-state analysis reveals decreased functional connectivity in major depression
Ilya M. Veer,Ilya M. Veer,Christian F. Beckmann,Christian F. Beckmann,Marie-José van Tol,Marie-José van Tol,Luca Ferrarini,Julien Milles,Dick J. Veltman,André Aleman,Mark A. van Buchem,Mark A. van Buchem,Nic J.A. van der Wee,Nic J.A. van der Wee,Serge A.R.B. Rombouts,Serge A.R.B. Rombouts +15 more
TL;DR: In this paper, the authors investigated whole-brain functional connectivity, unbiased by a priori definition of regions or networks of interest, in medication-free depressive patients without comorbidity.
Journal ArticleDOI
Assessing salivary cortisol in large-scale, epidemiological research.
Emma K. Adam,Meena Kumari +1 more
TL;DR: Examples of choices made, response rates obtained, and examples of results obtained from existing epidemiological cortisol studies are offered, as are suggestions for the modeling and interpretation of salivary cortisol data obtained in large-scale epidemiological research.
Journal ArticleDOI
Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study.
Sophie A. Vreeburg,Witte J.G. Hoogendijk,Johannes van Pelt,Roel H. DeRijk,Jolanda C. M. Verhagen,Richard van Dyck,Johannes H. Smit,Frans G. Zitman,Brenda W.J.H. Penninx +8 more
TL;DR: This large cohort study shows significant, although modest, associations between major depressive disorder and specific hypothalamic-pituitary-adrenal axis indicators and a higher cortisol awakening response was observed among both subjects with current MDD and subjects with remitted MDD, indicative of an increased biological vulnerability for depression.
References
More filters
Journal ArticleDOI
International physical activity questionnaire: 12-country reliability and validity
Cora L Craig,Alison L. Marshall,Michael Sjöström,Adrian Bauman,Michael L. Booth,Barbara E. Ainsworth,Michael Pratt,Ulf Ekelund,Agneta Yngve,James F. Sallis,Pekka Oja +10 more
TL;DR: Considering the diverse samples in this study, IPAQ has reasonable measurement properties for monitoring population levels of physical activity among 18- to 65-yr-old adults in diverse settings.
Journal ArticleDOI
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Ronald C. Kessler,Katherine A. McGonagle,Shanyang Zhao,Christopher B. Nelson,Michael R. Hughes,Suzann Eshleman,Hans-Ulrich Wittchen,Kenneth S. Kendler +7 more
TL;DR: The prevalence of psychiatric disorders is greater than previously thought to be the case, and morbidity is more highly concentrated than previously recognized in roughly one sixth of the population who have a history of three or more comorbid disorders.
Journal ArticleDOI
An inventory for measuring clinical anxiety: psychometric properties.
TL;DR: Un nouvel inventaire auto-administre destine a mesurer l'anxiete pathologique, le «Beck Anxiety Cheklist» (BAI) est decrit, evalue et compare au «Hamilton Anxiety Rating Scale» (test avec lequel des correlations moderees sont trouvees).
Journal ArticleDOI
The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.
TL;DR: A revision of the FTQ: the Fagerström Test for Nicotine Dependence (FTND), which found that a revised scoring of time to the first cigarette of the day (TTF) and number of cigarettes smoked per day (CPD) improved the scale.
Journal ArticleDOI
Measuring individual differences in implicit cognition: The implicit association test.
TL;DR: An implicit association test (IAT) measures differential association of 2 target concepts with an attribute when instructions oblige highly associated categories to share a response key, and performance is faster than when less associated categories share a key.