Intestinal absorption of water-soluble vitamins in health and disease
TLDR
The present review aims to outline the current understanding of the mechanisms involved in intestinal absorption of water-soluble vitamins, their regulation, the cell biology of the carriers involved and the factors that negatively affect these absorptive events.Abstract:
Our knowledge of the mechanisms and regulation of intestinal absorption of water-soluble vitamins under normal physiological conditions, and of the factors/conditions that affect and interfere with theses processes has been significantly expanded in recent years as a result of the availability of a host of valuable molecular/cellular tools. Although structurally and functionally unrelated, the water-soluble vitamins share the feature of being essential for normal cellular functions, growth and development, and that their deficiency leads to a variety of clinical abnormalities that range from anaemia to growth retardation and neurological disorders. Humans cannot synthesize water-soluble vitamins (with the exception of some endogenous synthesis of niacin) and must obtain these micronutrients from exogenous sources. Thus body homoeostasis of these micronutrients depends on their normal absorption in the intestine. Interference with absorption, which occurs in a variety of conditions (e.g. congenital defects in the digestive or absorptive system, intestinal disease/resection, drug interaction and chronic alcohol use), leads to the development of deficiency (and sub-optimal status) and results in clinical abnormalities. It is well established now that intestinal absorption of the water-soluble vitamins ascorbate, biotin, folate, niacin, pantothenic acid, pyridoxine, riboflavin and thiamin is via specific carrier-mediated processes. These processes are regulated by a variety of factors and conditions, and the regulation involves transcriptional and/or post-transcriptional mechanisms. Also well recognized now is the fact that the large intestine possesses specific and efficient uptake systems to absorb a number of water-soluble vitamins that are synthesized by the normal microflora. This source may contribute to total body vitamin nutrition, and especially towards the cellular nutrition and health of the local colonocytes. The present review aims to outline our current understanding of the mechanisms involved in intestinal absorption of water-soluble vitamins, their regulation, the cell biology of the carriers involved and the factors that negatively affect these absorptive events.read more
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References
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Book
Physiology of the Gastrointestinal Tract
TL;DR: Physiology of the Gastrointestinal Tract, Fifth Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.
Journal Article
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
Journal ArticleDOI
A family of mammalian Na + -dependent L -ascorbic acid transporters
Hiroyasu Tsukaguchi,Taro Tokui,Bryan Mackenzie,Urs V. Berger,Xing-Zhen Chen,Yangxi Wang,Richard F. Brubaker,Matthias A. Hediger,Matthias A. Hediger +8 more
TL;DR: It is found that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient.
Journal ArticleDOI
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
Andong Qiu,Michaela Jansen,Antoinette Sakaris,Sang Hee Min,Shrikanta Chattopadhyay,Eugenia Tsai,Claudio Sandoval,Rongbao Zhao,Myles H. Akabas,I. David Goldman +9 more
TL;DR: It is established that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and the name is amended to PCFT/HCP1.
Journal ArticleDOI
Identification of an intestinal heme transporter.
M Shayeghi,Gladys O. Latunde-Dada,Jonathan S. Oakhill,Abas H. Laftah,Ken Takeuchi,Neil Halliday,Yasmin Khan,Alice Warley,Fiona E. McCann,Robert C. Hider,David M. Frazer,Gregory J. Anderson,Chris D. Vulpe,Robert J. Simpson,Andrew T. McKie +14 more
TL;DR: A membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner and is indicated to be the long-sought intestinal heme transporter.
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