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基因科学与亲子鉴定——国际流行病与公众健康杂志J Epidemiol Community Health
徐晶(译)
- Iss: 9, pp 17-17
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The article was published on 2005-01-01 and is currently open access. It has received 474 citations till now.read more
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Journal ArticleDOI
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Timothy M. Frayling,Nicholas J. Timpson,Michael N. Weedon,Eleftheria Zeggini,Eleftheria Zeggini,Eleftheria Zeggini,Rachel M. Freathy,Cecilia M. Lindgren,John R. B. Perry,Katherine S. Elliott,Katherine S. Elliott,Hana Lango,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Beverley M. Shields,Lorna W. Harries,Jeffrey C. Barrett,Jeffrey C. Barrett,Sian Ellard,Christopher J. Groves,Christopher J. Groves,Bridget A. Knight,Ann-Marie Patch,Andy R Ness,Shah Ebrahim,Debbie A Lawlor,Susan M. Ring,Yoav Ben-Shlomo,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Ulla Sovio,Ulla Sovio,Amanda J. Bennett,Amanda J. Bennett,David Melzer,Luigi Ferrucci,Ruth J. F. Loos,Inês Barroso,Nicholas J. Wareham,Fredrik Karpe,Fredrik Karpe,Katharine R. Owen,Katharine R. Owen,Lon R. Cardon,Mark Walker,Graham A. Hitman,Graham A. Hitman,Colin N. A. Palmer,Colin N. A. Palmer,Alex S. F. Doney,Alex S. F. Doney,Andrew D. Morris,George Davey Smith,Andrew T. Hattersley,Mark I. McCarthy +55 more
TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
Journal ArticleDOI
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong,Victoria F. Beja-Glasser,Bianca M. Nfonoyim,Arnaud Frouin,Shaomin Li,Saranya Ramakrishnan,Katherine Merry,Qiaoqiao Shi,Arnon Rosenthal,Ben A. Barres,Cynthia A. Lemere,Dennis J. Selkoe,Beth Stevens,Beth Stevens +13 more
TL;DR: In mouse models, the complement-dependent pathway and microglia that prune excess synapses in development are inappropriately activated and mediate synapse loss in AD, which is an early feature of Alzheimer's disease and correlates with cognitive decline.
Journal ArticleDOI
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Bin Zhou,James Bentham,Mariachiara Di Cesare,Honor Bixby,Goodarz Danaei,Melanie J. Cowan,Christopher J. Paciorek,Gitanjali M. Singh,Kaveh Hajifathalian,James E. Bennett,Cristina Taddei,Ver Bilano,Rodrigo M. Carrillo-Larco,Shirin Djalalinia,Shahab Khatibzadeh,Charles Lugero,Niloofar Peykari,Wan Zhu Zhang,Yuan Lu,Gretchen A Stevens,Leanne M. Riley,Pascal Bovet,Paul Elliott,Dongfeng Gu,Nayu Ikeda,Rod Jackson,Michel Joffres,Andre Pascal Kengne,Tiina Laatikainen,Tai Hing Lam,Avula Laxmaiah,Jing Liu,J. Jaime Miranda,Charles Mondo,Hannelore Neuhauser,Johan Sundström,Liam Smeeth,Maroje Sorić,Mark Woodward,Majid Ezzati,Leandra Abarca-Gómez,Ziad Abdeen,Hanan F. Abdul Rahim,Niveen M E Abu-Rmeileh,Benjamin Acosta-Cazares,Robert J. Adams,Wichai Aekplakorn,Kaosar Afsana,Carlos A. Aguilar-Salinas,Charles Agyemang,Alireza Ahmadvand,Wolfgang Ahrens,Rajaa Al Raddadi,Rihab Al Woyatan,Mohamed M. Ali,Ala'a Alkerwi,Eman Aly,Philippe Amouyel,Antoinette Amuzu,Antoinette Amuzu,Lars Bo Andersen,Lars Bo Andersen,Sigmund A. Anderssen,Lars Ängquist,Ranjit Mohan Anjana,Daniel Ansong,Hajer Aounallah-Skhiri,Joana Araújo,Inger Ariansen,Tahir Aris,Nimmathota Arlappa,Krishna K. Aryal,Dominique Arveiler,Felix K. Assah,Maria Cecília Formoso Assunção,Maria Avdicova,Ana Azevedo,Fereidoun Azizi,Bontha V. Babu,Suhad Bahijri,Nagalla Balakrishna,Piotr Bandosz,José R. Banegas,José R. Banegas,Carlo M. Barbagallo,Alberto Barceló,Amina Barkat,Aluísio J D Barros,Mauro Virgílio Gomes de Barros,Iqbal Bata,Anwar Batieha,Louise A. Baur,Robert Beaglehole,Habiba Ben Romdhane,Mikhail Benet,Lowell S. Benson,Lowell S. Benson,Lowell S. Benson,Antonio Bernabe-Ortiz,Gailute Bernotiene,Heloisa Bettiol,Aroor Bhagyalaxmi,Sumit Bharadwaj,Santosh K. Bhargava,Yufang Bi,Mukharram M. Bikbov,Peter Bjerregaard,Espen Bjertness,Espen Bjertness,Cecilia Björkelund,Anneke Blokstra,Simona Bo,Martin Bobak,Heiner Boeing,José Boggia,Carlos P. Boissonnet,Vanina Bongard,L. Braeckman,Imperia Brajkovich,Francesco Branca,Juergen Breckenkamp,Hermann Brenner,Lizzy M. Brewster,Graziella Bruno,H. B. Bueno-De-Mesquita,Anna Bugge,Con Burns,Michael Bursztyn,Antonio Cabrera de León,Joseph Cacciottolo,Christine Cameron,Günay Can,Ana Paula Carlos Cândido,Vincenzo Capuano,Viviane Cunha Cardoso,Axel C. Carlsson,Maria J. Carvalho,Felipe F. Casanueva,Juan-Pablo Casas,Carmelo A. Caserta,Snehalatha Chamukuttan,Angelique Chan,Queenie Chan,Himanshu K. Chaturvedi,Nishi Chaturvedi,Chien-Jen Chen,Fangfang Chen,Huashuai Chen,Shuohua Chen,Zhengming Chen,Ching-Yu Cheng,Imane Cherkaoui Dekkaki,Angela Chetrit,Arnaud Chiolero,Arnaud Chiolero,Shu Ti Chiou,Adela Chirita-Emandi,Belong Cho,Belong Cho,Yumi Cho,Jerzy Chudek,Renata Cifkova,Frank Claessens,Frank Claessens,Els Clays,Hans Concin,Cyrus Cooper,Rachel Cooper,Tara Coppinger,Simona Costanzo,Dominique Cottel,Christopher T. Cowell,Christopher T. Cowell,Cora L. Craig,Ana B. Crujeiras,Juan J. Cruz,Graziella D'Arrigo,Eleonora d'Orsi,Jean Dallongeville,Albertino Damasceno,Rachel Dankner,Thomas Meinertz Dantoft,Luc Dauchet,Guy De Backer,Dirk De Bacquer,Giovanni de Gaetano,Stefaan De Henauw,Delphine De Smedt,Mohan Deepa,Abbas Dehghan,Helene Delisle,Valérie Deschamps,Klodian Dhana,Augusto Di Castelnuovo,Juvenal Soares Dias-da-Costa,Alejandro A. Diaz,Ty T. Dickerson,Ty T. Dickerson,Ty T. Dickerson,Ha T. P. Do,Annette J. Dobson,Chiara Donfrancesco,Silvana Donoso,Angela Döring,Kouamelan Doua,Wojciech Drygas,Virginija Dulskiene,Aleksandar Džakula,Vilnis Dzerve,Elżbieta Dziankowska-Zaborszczyk,Robert Eggertsen,Ulf Ekelund,Jalila El Ati,Ute Ellert,Roberto Elosua,Rajiv T Erasmus,Cihangir Erem,Louise Eriksen,Jorge Escobedo-de la Peña,Alun Evans,David Faeh,Caroline H.D. Fall,Farshad Farzadfar,Francisco J. Félix-Redondo,Trevor S. Ferguson,Daniel Fernández-Bergés,Daniel Ferrante,Marika Ferrari,Catterina Ferreccio,Jean Ferrières,Joseph D. Finn,Krista Fischer,Bernhard Föger,Leng Huat Foo,Ann-Sofie Forslund,Maria Forsner,Stephen P. Fortmann,Heba Fouad,Damian K Francis,Maria do Carmo Franco,Oscar H. Franco,Guillermo Frontera,Flávio Danni Fuchs,Sandra C. Fuchs,Yuki Fujita,Takuro Furusawa,Zbigniew Gaciong,Dickman Gareta,Sarah P. Garnett,Jean-Michel Gaspoz,Magda Gasull,Louise Gates,Diana Gavrila,Johanna M. Geleijnse,Anoosheh Ghasemian,Anup Ghimire,Simona Giampaoli,Francesco Gianfagna,Jonathan Giovannelli,Rebecca Goldsmith,Helen Gonçalves,Marcela González Gross,Marcela González Gross,Juan P. Gonzalez Rivas,Frederic Gottrand,Sidsel Graff-Iversen,Dusan Grafnetter,Aneta Grajda,Ronald D. Gregor,Tomasz Grodzicki,Anders Grøntved,Grabriella Gruden,Vera Grujic,Ong Peng Guan,Vilmundur Gudnason,Ramiro Guerrero,Idris Guessous,André Luiz Sena Guimarães,Martin Gulliford,Martin Gulliford,Johanna Gunnlaugsdottir,Marc J. Gunter,Prakash C. Gupta,Oye Gureje,Beata Gurzkowska,Laura Gutierrez,Felix Gutzwiller,Farzad Hadaegh,Jytte Halkjær,Ian Hambleton,Rebecca Hardy,Rachakulla Harikumar,Jun Hata,Alison J. Hayes,Jiang He,Marleen E. Hendriks,Ana Henriques,Leticia Hernandez Cadena,Sauli Herrala,Ramin Heshmat,Ilpo Tapani Hihtaniemi,Sai Yin Ho,Suzanne C. Ho,Michael Hobbs,Albert Hofman,Gönül Dinç,Claudia M. Hormiga,Bernardo L. Horta,Leila Houti,Christina Howitt,Thein Thein Htay,Aung Soe Htet,Yonghua Hu,José María Huerta,Abdullatif Husseini,Inge Huybrechts,Nahla Hwalla,Licia Iacoviello,Anna G. Iannone,Mohsen Ibrahim,M. Arfan Ikram,Vilma E. Irazola,Muhammad Islam,Vanja Ivković,Masanori Iwasaki,Jeremy M. Jacobs,Tazeen H. Jafar,Konrad Jamrozik,Imre Janszky,Grazyna Jasienska,Bojan Jelaković,Chaoqiang Jiang,Mattias Johansson,Jost B. Jonas,Torben Jørgensen,Pradeep Joshi,Anne Juolevi,Gregor Jurak,Vesna Jureša,Rudolf Kaaks,Anthony Kafatos,Ofra Kalter-Leibovici,Nor Azmi Kamaruddin,Amir Kasaeian,Joanne Katz,Jussi Kauhanen,Prabhdeep Kaur,Maryam Kavousi,Gyulli M. Kazakbaeva,Ulrich Keil,Lital Keinan Boker,Sirkka Keinänen-Kiukaanniemi,Roya Kelishadi,Han C. G. Kemper,Mathilde Kersting,Timothy J. Key,Yousef Khader,Davood Khalili,Young-Ho Khang,Kay-Tee Khaw,Stefan Kiechl,Japhet Killewo,Jeongseon Kim,Jurate Klumbiene,Elin Kolle,Patrick Kolsteren,Paul Korrovits,Seppo Koskinen,Katsuyasu Kouda,Slawomir Koziel,Peter Kristensen,Steinar Krokstad,Daan Kromhout,Herculina S. Kruger,Ruzena Kubinova,Renata Kuciene,Diana Kuh,Urho M. Kujala,Krzysztof Kula,Zbigniew Kułaga,R. Krishna Kumar,Pawel Kurjata,Yadlapalli S. Kusuma,Kari Kuulasmaa,Catherine Kyobutungi,Carl Lachat,Orlando Landrove,Vera Lanska,Georg Lappas,Bagher Larijani,Lars E. Laugsand,Khanh Le Nguyen Bao,Tuyen D Le,Catherine Leclercq,Catherine Leclercq,Jeannette Lee,Jeonghee Lee,Terho Lehtimäki,Rampal Lekhraj,Luz M. León-Muñoz,Luz M. León-Muñoz,Naomi S. Levitt,Yanping Li,Christa L Lilly,Christa L Lilly,Wei-Yen Lim,M. Fernanda Lima-Costa,Hsien-Ho Lin,Xu Lin,Allan Linneberg,Lauren Lissner,Mieczysław Litwin,Roberto Lorbeer,Paulo A. Lotufo,Jose Eugenio Lozano,Dalia Luksiene,Annamari Lundqvist,Nuno Lunet,Per Lytsy,Guansheng Ma,Jun Ma,George Luiz Lins Machado-Coelho,Suka Machi,Stefania Maggi,Dianna J. Magliano,Marjeta Majer,Marcia Makdisse,Reza Malekzadeh,Rahul Malhotra,Kodavanti Mallikharjuna Rao,Sofia Malyutina,Yannis Manios,Jim Mann,Enzo Manzato,Paula Margozzini,Pedro Marques-Vidal,Pedro Marques-Vidal,Jaume Marrugat,Reynaldo Martorell,Ellisiv B. Mathiesen,Alicia Matijasevich,Tandi E. Matsha,Jean Claude Mbanya,Anselmo J Mc Donald Posso,Shelly R. McFarlane,Stephen T. McGarvey,Stela McLachlan,Rachael McLean,Breige A. McNulty,Amir Sharifuddin Md Khir,Sounnia Mediene-Benchekor,Jurate Medzioniene,Aline Meirhaeghe,Christa Meisinger,Ana Maria Menezes,Geetha R Menon,Indrapal I. Meshram,Andres Metspalu,Jie Mi,Kairit Mikkel,Jody C Miller,Juan Francisco Miquel,Marjeta Mišigoj-Duraković,Mostafa K. Mohamed,Kazem Mohammad,Noushin Mohammadifard,Viswanathan Mohan,Muhammad Fadhli Mohd Yusoff,Niels Møller,Dénes Molnár,Amirabbas Momenan,Kotsedi D Monyeki,Leila Beltrami Moreira,Alain Morejon,Luis A. Moreno,Karen Morgan,George Moschonis,Małgorzata Mossakowska,Aya Mostafa,Jorge Mota,Mohammad Esmaeel Motlagh,Jorge Motta,Maria Lorenza Muiesan,Martina Müller-Nurasyid,Neil Murphy,Jaakko Mursu,Vera Musil,Gabriele Nagel,Balkish M. Naidu,Harunobu Nakamura,Jana Námešná,Ei Ei K. Nang,Vinay Nangia,Sameer Narake,Eva María Navarrete-Muñoz,Ndeye Coumba Ndiaye,William A. Neal,William A. Neal,Ilona Nenko,Flavio Nervi,Nguyen D Nguyen,Quang Ngoc Nguyen,Ramfis Nieto-Martínez,Teemu J. Niiranen,Guang Ning,Toshiharu Ninomiya,Sania Nishtar,Marianna Noale,Oscar Noboa,Ahmad Ali Noorbala,Teresa Noorbala,Davide Noto,Mohannad Al Nsour,Dermot O'Reilly,Kyungwon Oh,Maria Teresa Anselmo Olinto,Isabel O. Oliveira,Mohd Azahadi Omar,Altan Onat,Pedro Ordunez,Clive Osmond,Sergej M. Ostojic,Johanna A. Otero,Kim Overvad,Ellis Owusu-Dabo,Fred Paccaud,Cristina Padez,Elena Pahomova,Andrzej Pajak,Domenico Palli,Luigi Palmieri,Songhomitra Panda-Jonas,Francesco Panza,Dimitrios Papandreou,Winsome R. Parnell,Mahboubeh Parsaeian,Ivan Pećin,Mangesh S. Pednekar,Nasheeta Peer,Petra H.M. Peeters,Sérgio Viana Peixoto,Catherine Pelletier,Markku Peltonen,Alexandre C. Pereira,Rosa Marina Perez,Annette Peters,Janina Petkeviciene,Son Thai Pham,Iris Pigeot,Hynek Pikhart,Aida Pilav,Lorenza Pilotto,Freda Pitakaka,Pedro Plans-Rubio,Maria Polakowska,Ozren Polasek,Miquel Porta,Marileen L.P. Portegies,Akram Pourshams,Rajendra Pradeepa,Mathur Prashant,Jacqueline F. Price,Maria Puiu,Margus Punab,Radwan Qasrawi,Mostafa Qorbani,Ivana Radic,Ričardas Radišauskas,Mahfuzar Rahman,Olli T. Raitakari,Manu Raj,Sudha Ramachandra Rao,A. Ramachandran,Elisabete Ramos,Sanjay Rampal,Daniel A Rangel Reina,Finn Rasmussen,Josep Redon,Josep Redon,Paul Ferdinand M. Reganit,Robespierre Ribeiro,Elio Riboli,Fernando Rigo,Tobias F. Rinke de Wit,Raphael Mendes Ritti-Dias,Sian M. Robinson,Cynthia Robitaille,Fernando Rodríguez-Artalejo,Fernando Rodríguez-Artalejo,María Rodriguez-Perez del Cristo,Laura A. Rodríguez-Villamizar,Rosalba Rojas-Martínez,Annika Rosengren,Adolfo Rubinstein,Ornelas Rui,Blanca Sandra Ruiz-Betancourt,Andrea R. V. R. Horimoto,Marcin Rutkowski,Charumathi Sabanayagam,Harshpal Singh Sachdev,Olfa Saidi,Sibel Sakarya,Benoit Salanave,Eduardo Salazar Martinez,Diego Salmerón,Veikko Salomaa,Jukka T. Salonen,Jukka T. Salonen,Massimo Salvetti,Jose Sanchez-Abanto,Susana Sans,Diana A. Santos,Iná S. Santos,Renata Nunes dos Santos,Rute Santos,Jouko Saramies,Luís B. Sardinha,Giselle Sarganas Margolis,Nizal Sarrafzadegan,Kai-Uwe Saum,Savvas C. Savva,Marcia Scazufca,Herman Schargrodsky,Herman Schargrodsky,Ione Jayce Ceola Schneider,Constance Schultsz,Aletta E. Schutte,Aletta E. Schutte,Abhijit Sen,Idowu O Senbanjo,Sadaf G. Sepanlou,Sanjib Kumar Sharma,Jonathan E. Shaw,Kenji Shibuya,Dong Wook Shin,Dong Wook Shin,Youchan Shin,Rosalynn Siantar,Abla M. Sibai,Diego Augusto Santos Silva,Mary Simon,Judith Simons,Leon A. Simons,Michael Sjöström,Sine Skovbjerg,Jolanta Slowikowska-Hilczer,Przemyslaw Slusarczyk,Margaret Smith,Marieke B. Snijder,Hung-Kwan So,Eugene Sobngwi,Stefan Söderberg,Vincenzo Solfrizzi,Emily Sonestedt,Yi Song,Thorkild I. A. Sørensen,Charles Sossa Jérome,Aicha Soumare,Jan A. Staessen,Gregor Starc,Maria G. Stathopoulou,Bill Stavreski,Jostein Steene-Johannessen,Peter Stehle,Aryeh D. Stein,George S. Stergiou,Jochanan Stessman,Jutta Stieber,Doris Stöckl,Tanja Stocks,Jakub Stokwiszewski,Karien Stronks,Maria Wany Louzada Strufaldi,Chien-An Sun,Yn-Tz Sung,Paibul Suriyawongpaisal,Rody G. Sy,Rody G. Sy,E. Shyong Tai,Mari-Liis Tammesoo,Abdonas Tamosiunas,Abdonas Tamosiunas,Line Tang,Xun Tang,Frank Tanser,Yong Tao,Mohammed Rasoul Tarawneh,Carolina Tarqui-Mamani,Anne W. Taylor,Holger Theobald,Lutgarde Thijs,Betina H. Thuesen,Anne Tjønneland,Hanna Tolonen,Janne Schurmann Tolstrup,Murat Topbaş,Roman Topor-Madry,María José Tormo,Maties Torrent,Pierre Traissac,Dimitrios Trichopoulos,Antonia Trichopoulou,Oanh T. H. Trinh,Atul Trivedi,Lechaba Tshepo,Marshall K. Tulloch-Reid,Tomi-Pekka Tuomainen,Jaakko Tuomilehto,Maria L. Turley,Per Tynelius,Christophe Tzourio,Peter Ueda,Eunice Ugel,Hanno Ulmer,Hannu Uusitalo,Gonzalo Valdivia,Damaskini Valvi,Yvonne T. van der Schouw,Koen Van Herck,Lenie van Rossem,Irene G. M. van Valkengoed,Dirk Vanderschueren,Dirk Vanderschueren,Diego Vanuzzo,Lars J. Vatten,Tomas Vega,Gustavo Velasquez-Melendez,Giovanni Veronesi,W. M. Monique Verschuren,Roosmarijn Verstraeten,Cesar G. Victora,Lucie Viet,Eira Viikari-Juntura,Paolo Vineis,Jesús Vioque,Jyrki K. Virtanen,Sophie Visvikis-Siest,Bharathi Viswanathan,Peter Vollenweider,Peter Vollenweider,Sari Voutilainen,Ana Vrdoljak,Martine Vrijheid,Alisha N. Wade,Aline Wagner,Janette Walton,Wan Nazaimoon Wan Mohamud,Ming-Dong Wang,Qian Wang,Ya Xing Wang,S. Goya Wannamethee,Nicholas J. Wareham,Niels Wederkopp,Deepa Weerasekera,Peter H. Whincup,Kurt Widhalm,Kurt Widhalm,Indah Suci Widyahening,Andrzej Wiecek,Alet H. Wijga,Rainford J. Wilks,Johann Willeit,Peter Willeit,Emmanuel A. Williams,Tom Wilsgaard,Bogdan Wojtyniak,Tien Yin Wong,Roy A Wong-McClure,Jean Woo,Aleksander Giwercman Wu,Frederick C. W. Wu,Shou Ling Wu,Haiquan Xu,Weili Yan,Xiaoguang Yang,Xingwang Ye,Panayiotis K. Yiallouros,Akihiro Yoshihara,Novie O. Younger-Coleman,Ahmad Faudzi Yusoff,Muhammad Fadhli M Yusoff,Sabina Zambon,Tomasz Zdrojewski,Yi Zeng,Yi Zeng,Dong Zhao,Wenhua Zhao,Yingffeng Zheng,Dan Zhu,Esther Zimmermann,Julio Zuñiga Cisneros +790 more
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.
Journal ArticleDOI
The public health effect of economic crises and alternative policy responses in Europe: an empirical analysis
David Stuckler,David Stuckler,Sanjay Basu,Sanjay Basu,Marc Suhrcke,Adam Coutts,Michael McKee,Michael McKee +7 more
TL;DR: Rises in unemployment are associated with significant short-term increases in premature deaths from intentional violence, while reducing traffic fatalities, and active labour market programmes that keep and reintegrate workers in jobs could mitigate some adverse health effects of economic downturns.
Journal ArticleDOI
Global patterns of mortality in young people: a systematic analysis of population health data
George C Patton,George C Patton,Carolyn Coffey,Susan M Sawyer,Susan M Sawyer,Russell M Viner,Dagmar M. Haller,Krishna Bose,Theo Vos,Jane F. Ferguson,Colin Mathers +10 more
TL;DR: Present global priorities for adolescent health policy are an important but insufficient response to prevent mortality in an age-group in which more than two in five deaths are due to intentional and unintentional injuries.
References
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Journal ArticleDOI
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Timothy M. Frayling,Nicholas J. Timpson,Michael N. Weedon,Eleftheria Zeggini,Eleftheria Zeggini,Eleftheria Zeggini,Rachel M. Freathy,Cecilia M. Lindgren,John R. B. Perry,Katherine S. Elliott,Katherine S. Elliott,Hana Lango,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Beverley M. Shields,Lorna W. Harries,Jeffrey C. Barrett,Jeffrey C. Barrett,Sian Ellard,Christopher J. Groves,Christopher J. Groves,Bridget A. Knight,Ann-Marie Patch,Andy R Ness,Shah Ebrahim,Debbie A Lawlor,Susan M. Ring,Yoav Ben-Shlomo,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Ulla Sovio,Ulla Sovio,Amanda J. Bennett,Amanda J. Bennett,David Melzer,Luigi Ferrucci,Ruth J. F. Loos,Inês Barroso,Nicholas J. Wareham,Fredrik Karpe,Fredrik Karpe,Katharine R. Owen,Katharine R. Owen,Lon R. Cardon,Mark Walker,Graham A. Hitman,Graham A. Hitman,Colin N. A. Palmer,Colin N. A. Palmer,Alex S. F. Doney,Alex S. F. Doney,Andrew D. Morris,George Davey Smith,Andrew T. Hattersley,Mark I. McCarthy +55 more
TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
Journal ArticleDOI
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong,Victoria F. Beja-Glasser,Bianca M. Nfonoyim,Arnaud Frouin,Shaomin Li,Saranya Ramakrishnan,Katherine Merry,Qiaoqiao Shi,Arnon Rosenthal,Ben A. Barres,Cynthia A. Lemere,Dennis J. Selkoe,Beth Stevens,Beth Stevens +13 more
TL;DR: In mouse models, the complement-dependent pathway and microglia that prune excess synapses in development are inappropriately activated and mediate synapse loss in AD, which is an early feature of Alzheimer's disease and correlates with cognitive decline.
Journal ArticleDOI
The public health effect of economic crises and alternative policy responses in Europe: an empirical analysis
David Stuckler,David Stuckler,Sanjay Basu,Sanjay Basu,Marc Suhrcke,Adam Coutts,Michael McKee,Michael McKee +7 more
TL;DR: Rises in unemployment are associated with significant short-term increases in premature deaths from intentional violence, while reducing traffic fatalities, and active labour market programmes that keep and reintegrate workers in jobs could mitigate some adverse health effects of economic downturns.
Journal ArticleDOI
Global patterns of mortality in young people: a systematic analysis of population health data
George C Patton,George C Patton,Carolyn Coffey,Susan M Sawyer,Susan M Sawyer,Russell M Viner,Dagmar M. Haller,Krishna Bose,Theo Vos,Jane F. Ferguson,Colin Mathers +10 more
TL;DR: Present global priorities for adolescent health policy are an important but insufficient response to prevent mortality in an age-group in which more than two in five deaths are due to intentional and unintentional injuries.
Journal ArticleDOI
Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis
Vicki Flenady,Laura Koopmans,Philippa Middleton,J. Frederik Frøen,Gordon C. S. Smith,Kristen Gibbons,Michael Coory,Adrienne Gordon,David Ellwood,Harold David McIntyre,Ruth C. Fretts,Majid Ezzati +11 more
TL;DR: The raising of awareness and implementation of effective interventions for modifiable risk factors, such as overweight, obesity, maternal age, and smoking, are priorities for stillbirth prevention in high-income countries.