Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer.
Rozita Bagheri-Yarmand,Krishna M. Sinha,Ling Li,Yue Lu,Gilbert J. Cote,Steven I. Sherman,Robert F. Gagel +6 more
TL;DR: Findings reveal a combination therapy that induces reactive oxygen species–dependent catastrophic cell death through induction of ATF4 and KLF9 transcriptional activity and identified ATF4 target genes that were synergistically upregulated with the combination of TKI and ERAD inhibitor.
Journal ArticleDOI
The role of KLF14 in multiple disease processes.
TL;DR: The functions of KLF14 are reviewed in physiologyical and pathological process, which include regulating cell signaling pathways, cell proliferation and differentiation, and tumorigenesis and immune regulation.
Journal ArticleDOI
Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells
Roberta Fajka-Boja,Annamária Marton,Anna Tóth,Péter Blazsó,Vilmos Tubak,Balázs Bálint,István Nagy,Zoltán Hegedűs,Csaba Vizler,Robert L. Katona +9 more
TL;DR: It is found that elevated production of insulin-like growth factor 1 by polyploid ASCs rendered them more potent in tumor growth promotion in vitro, indicating how ASCs with altered genetic background may support tumor progression.
Journal ArticleDOI
Context-dependent functions of KLF4 in cancers: Could alternative splicing isoforms be the key?
TL;DR: Detailed study of KLf4 alternative splicing may not only provide new insights into the complexity of KLF4 functions but also lead to rational targeting of KlF4 for cancer prevention and therapy.
Journal ArticleDOI
NF-κB deregulation in splenic marginal zone lymphoma
Valeria Spina,Davide Rossi +1 more
TL;DR: The progress in understanding the mechanism of NF-κB activation in splenic marginal zone lymphoma is described, including molecular, epigenetic and post-transcriptional modifications of NF -κB genes and of upstream pathways are described, and how information gained has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance.
References
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