Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
Selective Interactions of Krüppel-like Factor 9/Basic Transcription Element-binding Protein with Progesterone Receptor Isoforms A and B Determine Transcriptional Activity of Progesterone-responsive Genes in Endometrial Epithelial Cells
Xue-Lian Zhang,Daying Zhang,Frank J. Michel,Jason L. Blum,Frank A. Simmen,Frank A. Simmen,Rosalia C. M. Simmen,Rosalia C. M. Simmen +7 more
TL;DR: It is reported that BTEB1 can mediate signaling pathways involving the nuclear receptor for the steroid hormone progesterone in endometrial epithelial cells by its selective interaction with the progester one receptor (PR) isoforms, PR-A and PR-B.
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Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells.
TL;DR: The results indicate that BTEB2 is a target of the early-response gene Egr-1, and mitogen-activated protein kinase pathways directly or indirectly activate BTEBs expression, which may represent at least one of the molecular mechanisms underlying phenotypic modulation of smooth muscles after vascular injury.
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Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ERβ and KLF5
Yuka Nakajima,Kensuke Akaogi,Takashi Suzuki,Asami Osakabe,Chie Yamaguchi,Nanae Sunahara,Junji Ishida,Koichiro Kako,Sonoko Ogawa,Tetsuya Fujimura,Yukio Homma,Akiyoshi Fukamizu,Akiko Murayama,Keiji Kimura,Satoshi Inoue,Satoshi Inoue,Junn Yanagisawa +16 more
TL;DR: It is demonstrated that the estrogen receptor β (ERβ) mediates inhibition by the antiestrogen ICI 182,780 (ICI) and its enhancement by estrogen, and affects prostate tumor growth through ERβ-mediated regulation of KLF5.
Journal ArticleDOI
Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.
TL;DR: It is demonstrated that forced expression of Klf4 in murine HCC cell lines reduced anchorage-independent growth in soft agar as well as cell migration and invasion activities in vitro and suggest that KLF4 acts as a tumor suppressor in HCC cells, in part by suppressing SLUG transcription.
Journal ArticleDOI
Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)
TL;DR: The results indicate that the genomic structure and erythroid-restricted expression of EKLF are highly conserved between the murine and human homologues.