Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells
TL;DR: The data suggest that COX‐derived PGE2 may collaborate with KLF4/5 to regulate the activation of the complement system and exert diverse effects on the intestinal epithelium.
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Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias.
TL;DR: A number of publications have provided evidence of the implication of Krüppel-like factor proteins in gastrointestinal carcinogenesis and this article will focus on the results of studies in the field published in the last year.
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Mouse lactoferrin gene. Promoter-specific regulation by EGF and cDNA cloning of the EGF-response-element binding protein.
TL;DR: Protein-protein interaction among the transcription factors could fine-tune the mouse lactoferrin expression in various tissues and was found to be promoter specific in RL95-2 cells.
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The human papillomavirus-16 (HPV-16) oncoprotein E7 conjugates with and mediates the role of the transforming growth factor-beta inducible early gene 1 (TIEG1) in apoptosis
TL;DR: The results indicate that E7 binds to the C-terminus of TIEG1 and induces its degradation via the ubiquitin pathway, and suggests that suppression ofTIEG1-mediated signaling by E7 may contribute to HPV-associated carcinogenesis.
Journal ArticleDOI
KLF6 in nonalcoholic fatty liver disease: role of fibrogenesis and carcinogenesis.
TL;DR: Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants—Hakomori’s concepts revisited is revisited.