Journal ArticleDOI
Krüppel-like factors in cancer
Reads0
Chats0
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
More filters
Journal ArticleDOI
Up-regulation of miR-181a in clear cell renal cell carcinoma is associated with lower KLF6 expression, enhanced cell proliferation, accelerated cell cycle transition, and diminished apoptosis.
Zhenwei Lei,Xin Ma,Hongzhao Li,Yu Zhang,Yu Gao,Yang Fan,Xintao Li,Luyao Chen,Yongpeng Xie,Jianwen Chen,Shengpan Wu,Lu Tang,Xu Zhang +12 more
TL;DR: In this paper, the effects of miR-181a on cell proliferation, colony formation, cell cycle progression, and apoptosis were investigated in clear cell renal cell carcinoma (ccRCC) tissues and cancer cell lines.
Journal ArticleDOI
Role of the reprogramming factor KLF4 in blood formation
TL;DR: Evidence suggests that Krüppel‐like factor 4 regulates the development and function of the myeloid and lymphoid blood lineages and emerging interest in the redifferentiation of induced pluripotent stem cells into blood cells to correct hematologic deficiencies and malignancies warrants further studies on the role.
Journal ArticleDOI
HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer.
Vineesh Indira Chandran,Serenella Eppenberger-Castori,Thejaswini Venkatesh,Kara L. Vine,Marie Ranson +4 more
TL;DR: An improved understanding of the HER2/uPAR interaction in breast cancer will provide critical biomolecular information that may help better predict disease course and response to therapy.
Journal ArticleDOI
Extracting a low-dimensional description of multiple gene expression datasets reveals a potential driver for tumor-associated stroma in ovarian cancer
Safiye Celik,Benjamin A. Logsdon,Stephanie L. Battle,Charles W. Drescher,Mara H. Rendi,R. David Hawkins,Su-In Lee +6 more
TL;DR: The INSPIRE method is presented to infer modules of co-expressed genes and the dependencies among the modules from multiple expression datasets that may contain different sets of genes, and shows that it infers more accurate models than existing methods to extract low-dimensional representation of expression data.
Journal ArticleDOI
ZNF32 induces anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling in hepatocellular carcinoma
Kai Li,Gang Zhao,Jie Ao,Di Gong,Jie Zhang,Yue Chen,Jun Li,Lugang Huang,Rong Xiang,Jiankun Hu,Ping Lin,Yuquan Wei +11 more
TL;DR: Mechanistically, it is demonstrated that ZNF32 overexpression suppresses the reactive oxygen species (ROS) accumulation and maintains mitochondrial membrane potential, leading to ATP, GSH and NADPH elevation and promoting HCC cell survival in response to suspension and the potential therapeutic value of ZNF 32 in HCC patients is suggested.
References
More filters
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Phylogeny.fr: robust phylogenetic analysis for the non-specialist
Alexis Dereeper,Valentin Guignon,Guillaume Blanc,Stéphane Audic,S. Buffet,François Chevenet,Jean-François Dufayard,Stéphane Guindon,Vincent Lefort,Magali Lescot,Jean-Michel Claverie,Olivier Gascuel +11 more
TL;DR: The Phylogeny.fr platform transparently chains programs to automatically perform phylogenetic analyses and can also meet the needs of specialists; the first ones will find up-to-date tools chained in a phylogeny pipeline to analyze their data in a simple and robust way, while the specialists will be able to easily build and run sophisticated analyses.
Journal ArticleDOI
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.