Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
TL;DR: In this paper , the authors examined the role of mammalian cleavage factor I 25 kD subunit (CFIm25, NUDT21) in inhibiting hepatic stellate cell activation.
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Discovery of Klf2 interactors in mouse embryonic stem cells by immunoprecipitation-mass spectrometry utilizing exogenously expressed bait
TL;DR: In this paper, a modified immunoprecipitation-mass spectrometry (IP-MS) method was designed to carry out a thorough survey of the Klf2 interactome in embryonic stem cells and identify novel transcription cofactors.
References
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Phylogeny.fr: robust phylogenetic analysis for the non-specialist
Alexis Dereeper,Valentin Guignon,Guillaume Blanc,Stéphane Audic,S. Buffet,François Chevenet,Jean-François Dufayard,Stéphane Guindon,Vincent Lefort,Magali Lescot,Jean-Michel Claverie,Olivier Gascuel +11 more
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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
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