Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression.
Chenyang Huang,Yue Jiang,Jianjun Zhou,Qiang Yan,Ruiwei Jiang,Xi Cheng,Jun Xing,Lijun Ding,Jianxin Sun,Guijun Yan,Haixiang Sun +10 more
TL;DR: KLF12 impairs endometrial decidialization by transcriptionally repressing Nur77, and Nur77 overexpression reverses the poor decidual response of hESCs in RIF patients.
Journal ArticleDOI
KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer
Xiaozhong Xiong,Markus Schober,Evelyne Tassone,Alireza Khodadadi-Jamayran,Ana Sastre-Perona,Hua Zhou,Aristotelis Tsirigos,Steven S. Shen,Miao Chang,Jonathan Melamed,Liliana Ossowski,Elaine L. Wilson +11 more
TL;DR: It is proposed that genes that control adult stem cell homeostasis in organs with slow turnover, such as the prostate, control cancer fate and KLF4, overexpressed in murine prostate stem cells, regulates theirHomeostasis, blocks malignant transformation, and controls the self-renewal of tumor-initiating cells.
Journal ArticleDOI
Novel tumor-suppressor function of KLF4 in pediatric T-cell acute lymphoblastic leukemia
TL;DR: The present review summarizes the role of the KLF4-MAP2K7 pathway in T-ALL pathogenesis and the function of JNK and MAP2k7 in carcinogenesis and therapy.
Journal ArticleDOI
Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers
Hatice U. Osmanbeyoglu,Hatice U. Osmanbeyoglu,Fumiko Shimizu,Angela Rynne-Vidal,Direna Alonso-Curbelo,Hsuan An Chen,Hannah Y Wen,Tsz-Lun Yeung,Petar Jelinic,Pedram Razavi,Scott W. Lowe,Samuel C. Mok,Gabriela Chiosis,Douglas A. Levine,Christina S. Leslie +14 more
TL;DR: A computational strategy called PSIONIC (patient-specific inference of networks informed by chromatin) is developed to combine chromatin accessibility data with large tumor expression data and model the effect of enhancers on transcriptional programs in multiple cancers.
Journal ArticleDOI
Excessive miR-152-3p Results in Increased BAFF Expression in SLE B-Cells by Inhibiting the KLF5 Expression
TL;DR: This study confirmed that Kruppel-like factor 5 (KLF5) was a direct target of miR-152-3p, and it could bind to the promoter region of BAFF and inhibit its expression in B-cells, leading to an increase in BAFF expression by inhibiting KLF5 expression.
References
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