Journal ArticleDOI
Krüppel-like factors in cancer
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
SUMOylation Regulates Nuclear Localization of Krüppel-like Factor 5
TL;DR: It is shown that mouse KLF5 is SUMOylated at lysine residues 151 and 202, suggesting thatsumOylation enhances nuclear localization of KLF4 and enhances the ability of KLf5 to stimulate anchorage-independent growth of HCT116 colon cancer cells.
Journal ArticleDOI
Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis.
TL;DR: It is proposed that KLF4 expression is associated with human skin SCC progression and metastases.
Journal ArticleDOI
KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing
Sanhita Ray,Jeffrey W. Pollard +1 more
TL;DR: In vivo expression of KLF15 in an estrogenized uterus mimics P4’s action by inhibiting E2-induced uterine epithelial MCM-2 expression and DNA synthesis, and is therefore a downstream physiological mediator of progesterone's cell cycle inhibitory action in the uterusine epithelium.
Journal ArticleDOI
KLF4 is a Novel Candidate Tumor Suppressor Gene in Pancreatic Ductal Carcinoma
Francesca Zammarchi,Mariangela Morelli,Michele Menicagli,Claudio Di Cristofano,Katia Zavaglia,Alessandra Paolucci,Daniela Campani,Paolo Aretini,Ugo Boggi,Franco Mosca,Andrea Cavazzana,Luca Cartegni,Generoso Bevilacqua,Chiara Maria Mazzanti +13 more
TL;DR: A novel oncosuppressor region located at the 9q 31.1-3 locus that is lost in DPC at high frequency is identified, suggesting a key suppressor role in pancreatic tumorigenesis.
Journal ArticleDOI
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.
Yukiko Nakahara,Paul A. Northcott,Meihua Li,Paul Kongkham,Christian A. Smith,Hai Yan,Sidney Croul,Young Shin Ra,Charles G. Eberhart,Annie Huang,Darrell D. Bigner,Wesia Grajkowska,Timothy E. Van Meter,James T. Rutka,Michael D. Taylor +14 more
TL;DR: It is concluded that KLF4 is inactivated by either genetic or epigenetic mechanisms in a large subset of medulloblastomas and that it likely functions as a tumor suppressor gene in the pathogenesis of medULLoblastoma.