Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
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Aberrant regulation of FBW7 in cancer
TL;DR: Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy.
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Feedback regulation of TGF-β signaling.
TL;DR: This review discusses how each step of TGF-β signaling is finely controlled by distinct modes of feedback mechanisms, involving both protein regulators and miRNAs.
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miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro.
Fabian M Troschel,Nicolas Böhly,Katrin Borrmann,Timo Braun,Alexander Schwickert,Ludwig Kiesel,Hans Theodor Eich,Martin Götte,Burkhard Greve +8 more
TL;DR: It is concluded that miR-142-3p downregulates cancer stem cell characteristics and radioresistance in breast cancer, mediated by a reduced role of β-catenin in miR–miR–overexpressing cells.
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Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma
TL;DR: Clinical implications of two intrinsic subtypes of ESCC were identified based on expression profiles of lncRNA and mRNA and functional cooperation of multiple lncRNAs was discovered in the two differential mRNA-lncRNA crosstalk networks, which systematically uncovered the roles of lNCRNAs as ceRNAs implicated in ESCC.
Journal ArticleDOI
Molecular and translational advances in meningiomas.
Suganth Suppiah,Farshad Nassiri,Wenya Linda Bi,Ian F. Dunn,Clemens Oliver Hanemann,Craig Horbinski,Rintaro Hashizume,Charles David James,Christian Mawrin,Houtan Noushmehr,Arie Perry,Felix Sahm,Andrew E. Sloan,Andreas von Deimling,Patrick Y. Wen,Kenneth Aldape,Gelareh Zadeh +16 more
TL;DR: The most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation are reviewed, and the landscape of available preclinical models in meningingiomas is highlighted.
References
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