Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression
Amjad Ali,Peng Zhang,Liangfang Y,Wenshe S,Wang H,Lin X,Dai Y,Feng Xh,Robb E. Moses,Wang D,Xiaotao Li,Jianru Xiao +11 more
TL;DR: This work shows that enhance KLF17 activity has important therapeutic implications for targeted-therapies aimed at TGF-β/Smad3 pathway and defines new insights into anti-metastatic functions of Kruppel-like-factor 17.
Journal ArticleDOI
Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6
Ao-Di He,Wen Xie,Wei Song,Yuan-yuan Ma,Gang Liu,Ming-Lu Liang,Xing-Wen Da,Guang-Qiang Yao,Bi-xiang Zhang,Cunji Gao,Jizhou Xiang,Zhang-Yin Ming +11 more
TL;DR: It is concluded that platelet releasates, especially TGF-β, promote the proliferation of SMMC.7721 and HepG2 cells by decreasing expression of KLF6, identifying a potential new therapeutic target for the prevention and treatment of hepatocellular carcinoma.
Journal ArticleDOI
Axon plasticity in the mammalian central nervous system after injury
Meifan Chen,Binhai Zheng +1 more
TL;DR: Animal studies demonstrate the potential to achieve significant anatomical repair and functional recovery following CNS injury by manipulating axon growth regulators alone or in combination with activity-dependent strategies.
Journal ArticleDOI
O-GlcNAc Transferase Regulates Cancer Stem-like Potential of Breast Cancer Cells.
Neha M. Akella,Giang Le Minh,Lorela Ciraku,Ayonika Mukherjee,Zachary A. Bacigalupa,Dimpi Mukhopadhyay,Valerie L. Sodi,Mauricio J. Reginato +7 more
TL;DR: These findings demonstrate that OGT plays a key role in the regulation of breast CSCs in vitro and tumor initiation in vivo, in part, via regulation of KLF8, and thus inhibition of OGT may serve as a therapeutic strategy to regulate tumor-initiating activity.
Journal ArticleDOI
Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration.
Jun Wan,Yijing Su,Qifeng Song,Brian Tung,Brian Tung,Olutobi Oyinlade,Sheng Liu,Mingyao Ying,Mingyao Ying,Guo Li Ming,Hongjun Song,Jiang Qian,Heng Zhu,Shuli Xia +13 more
TL;DR: The biological function of mCpG-dependent gene regulation by KLF4 in glioblastoma cells is reported, demonstrating a new paradigm of DNA methylation-mediated gene activation and chromatin remodeling, and providing a general framework to dissect the biological functions ofDNA methylation readers and effectors.
References
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