Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma.
Yi-ning Li,Shuo Tu,Yi Zeng,Cheng Zhang,Tian Deng,Weicheng Luo,Lingyan Lian,Ling Chen,Xiangyang Xiong,Xiaohua Yan +9 more
TL;DR: The results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-β signaling.
Journal ArticleDOI
Emerging Roles of GLI-Similar Krüppel-like Zinc Finger Transcription Factors in Leukemia and Other Cancers
TL;DR: An overview of the critical roles genetic changes in GLIS1-3 play in the development of several malignancies is provided and Targeting upstream signaling pathways that regulate GLIS signaling may offer new therapeutic strategies in the management of cancer.
Journal ArticleDOI
Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment.
Shweta Arora,Prithvi Singh,Shaniya Ahmad,Tanveer Ahmad,Ravins Dohare,Saleh A. Almatroodi,Faris Alrumaihi,Arshad Husain Rahmani,Mansoor Ali Syed +8 more
TL;DR: In this article, the role of microRNAs in macrophage polarization during the development of non-small cell lung cancer (NSCLC) was investigated, and it was shown that miR-34a-5p mediated targeting of these molecular networks will provide a better therapeutic intervention for NSCLC patients.
Journal ArticleDOI
New insights of Krüppel-like transcription factors in adipogenesis and the role of their regulatory neighbors.
TL;DR: This review focuses on the transcriptional role that KLF family members play during adipocyte differentiation, describes their main interactions and the mechanisms involved in this fine-tuned developmental process, and summarizes new findings of the involvement of several effectors that modulate KLFs expression during adipogenesis.
Journal ArticleDOI
KLF15 regulates in vitro chondrogenic differentiation of human mesenchymal stem cells by targeting SOX9.
TL;DR: Investigation of the function of the Kruppel-like factor (KLF) transcriptional factor family in regulating chondrogenic differentiation from human MSCs shows that KLF15 promotes chondrogensic differentiation of human M SCs by activating SOX9.
References
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