Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Additional file 3: Figure S2. of MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
Celia Mak,Mingo Yung,Lynn Hui,Leanne Leung,Rui Liang,Kangmei Chen,Stephanie Liu,Yiming Qin,Thomas Leung,Kai-Fai Lee,Karen Chan,Hextan Ys Ngan,David Chan +12 more
TL;DR: Wang et al. as mentioned in this paper identified a novel signaling axis of miR-141/KLF12/Sp1/survivin in enhancing anoikis resistance and likely serves as a potential therapeutic target for metastatic ovarian cancer.
Journal ArticleDOI
miR-214-5p targets KLF5 and suppresses proliferation of human hepatocellular carcinoma cells.
TL;DR: This study explored miR‐214‐5p expression status in 78 paired tumor and nontumor tissues obtained from patients with hepatocellular carcinoma by RT‐qPCR and suggested it functions as a tumor suppressor through targeting KLF5 in HCC.
Journal ArticleDOI
Transcription Factor KLF14 and Metabolic Syndrome.
Qianyi Yang,Mete Civelek +1 more
TL;DR: Common attributes of its biochemical, physiological, and pathophysiological roles are described and the current challenges in understanding the role of KLF14 in metabolism are discussed and suggestions for future directions are provided.
Journal ArticleDOI
Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation.
Savvas Petanidis,Kalliopi Domvri,Konstantinos Porpodis,Doxakis Anestakis,Lutz Freitag,Wolfgang Hohenforst-Schmidt,Drosos Tsavlis,Konstantinos Zarogoulidis +7 more
TL;DR: The multifaceted roles of Kras-derived exosomes are demonstrated in sustaining lung immunosuppressive metastasis and provide new opportunities for effective metastasis inhibition, especially in chemoresistant tumors.
Journal ArticleDOI
Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma.
Jia Mai,Zhuo Yan Zhong,Gui Fang Guo,Xiu Xing Chen,Yan Qun Xiang,Xuan Li,Hai Liang Zhang,Yu Hong Chen,Xue Lian Xu,Rui Yan Wu,Yan Yu,Zhi Ling Li,Xiao Dan Peng,Yun Huang,Li Huan Zhou,Gong Kan Feng,Xiang Guo,Rong Deng,Xiao Feng Zhu +18 more
TL;DR: It is found that KLF4 played as a tumor-promoting gene in NPC, and could be mediated by PLK1, and this study unveiled a newPLK1-TRAF6-KLF4 feed-forward loop.
References
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