Journal ArticleDOI
Krüppel-like factors in cancer
Reads0
Chats0
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
More filters
Journal ArticleDOI
Krüppel Like Factors Family Expression in Cervical Cancer Cells
Daniel Marrero-Rodríguez,Hugo Arreola-De la Cruz,Keiko Taniguchi-Ponciano,Laura Gomez-Virgilio,Victor Huerta-Padilla,Gustavo Ponce-Navarrete,Sergio Andonegui-Elguera,Florinda Jiménez-Vega,Pablo Romero-Morelos,Miriam Rodríguez-Esquivel,Marco Antonio Meraz-Ríos,Ma. del Pilar Figueroa-Corona,Alberto Monroy,Oscar Pérez-González,Mauricio Salcedo +14 more
TL;DR: It is suggested that KLF expression could not be related to HPV presence/genotype, at least at transcriptional level, and the expression of KLF family members may be necessary in the biology of the CC cells.
Journal ArticleDOI
The transcription factor Klf5 is essential for intrahepatic biliary epithelial tissue remodeling after cholestatic liver injury
Hajime Okada,Minami Yamada,Kenji Kamimoto,Cindy Kok,Kota Kaneko,Masatsugu Ema,Atsushi Miyajima,Tohru Itoh +7 more
TL;DR: It is demonstrated that the transcription factor Krüppel-like factor 5 (Klf5) is highly enriched in mouse liver BECs and plays a key role in regulating the ductular reaction, specifically under cholestatic injury conditions.
Journal ArticleDOI
KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer.
TL;DR: In vitro and in vivo experiments both demonstrated that depleting KLF16 significantly inhibited the growth of PCa cells, and bioinformatics analysis showed that KLf16 may be required for PCa development.
Journal ArticleDOI
Radiotherapy in combination with hyperthermia suppresses lung cancer progression via increased NR4A3 and KLF11 expression
Beomseok Son,Jaewan Jeon,Jaewan Jeon,Sungmin Lee,Hyun-Woo Kim,Hyunkoo Kang,HyeSook Youn,Sunmi Jo,BuHyun Youn +8 more
TL;DR: The results suggest that NR4A3 and KLF11 are critical for increasing the efficacy of radiotherapy in combination with HT, and the effect of these two factors on lung cancer progression was evaluated by in vivo xenograft studies.
Journal ArticleDOI
Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins.
Hansong Sheng,Fang Shen,Nu Zhang,Lisheng Yu,Xiangqi Lu,Zhe Zhang,Huang-Yi Fang,Ling-Li Zhou,Jian Lin +8 more
TL;DR: The data suggest the two meningiomas might develop independently in this patient and molecular subtyping by NGS is a valuable supplement to conventional pathology.
References
More filters
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Phylogeny.fr: robust phylogenetic analysis for the non-specialist
Alexis Dereeper,Valentin Guignon,Guillaume Blanc,Stéphane Audic,S. Buffet,François Chevenet,Jean-François Dufayard,Stéphane Guindon,Vincent Lefort,Magali Lescot,Jean-Michel Claverie,Olivier Gascuel +11 more
TL;DR: The Phylogeny.fr platform transparently chains programs to automatically perform phylogenetic analyses and can also meet the needs of specialists; the first ones will find up-to-date tools chained in a phylogeny pipeline to analyze their data in a simple and robust way, while the specialists will be able to easily build and run sophisticated analyses.
Journal ArticleDOI
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.