Journal ArticleDOI
Krüppel-like factors in cancer
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
Opposing Effects of Krüppel-like Factor 4 (Gut-Enriched Krüppel-like Factor) and Krüppel-like Factor 5 (Intestinal-Enriched Krüppel-like Factor) on the Promoter of the Krüppel-like Factor 4 Gene
TL;DR: It is demonstrated that Klf5 binds to a number of cis-DNA elements that have previously been shown to bind to Klf4, and the opposing effect of the two Klfs on theKlf4 promoter activity may provide a basis for the coordinated regulation of expression of the Klf 4 gene in the intestinal epithelium.
Journal ArticleDOI
Roles of KLF6 and KLF6-SV1 in Ovarian Cancer Progression and Intraperitoneal Dissemination
Analisa DiFeo,Goutham Narla,Jennifer Hirshfeld,Olga Camacho-Vanegas,Jyothsna Narla,Stephen L. Rose,Tamara Kalir,Shen Yao,Alice C. Levine,Michael J. Birrer,Tomas Bonome,Scott L. Friedman,Richard E. Buller,John A. Martignetti +13 more
TL;DR: The results show that KLF 6 and KLF6-SV1 are associated with key clinical features of EOC and suggest that their therapeutic targeting may alter ovarian cancer growth, progression, and dissemination.
Journal ArticleDOI
Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene.
Xiaolong Wei,Hai Xu,Donald Kufe +2 more
TL;DR: The results show that overexpression of MUC1, as found in human breast cancer cells, is of functional importance to repression of the p53 gene and that M UC1-C increases the recruitment of histone deacetylases 1/3, deacetYLation of core histones, and repression of p53 transcription.
Journal ArticleDOI
Expression of KLF5 is a Prognostic Factor for Disease-Free Survival and Overall Survival in Patients with Breast Cancer
Dan Tong,Klaus Czerwenka,Georg Heinze,Martin Ryffel,Eva Schuster,Armin Witt,Sepp Leodolter,Robert Zeillinger +7 more
TL;DR: The gene expression of KLf5 is directly correlated with cell proliferation in vivo and is a prognostic factor for patients with breast cancer, and patients with higher KLF5 expression have shorter disease-free survival and overall survival than patients with lower KLF 5 expression.