Journal ArticleDOI
Krüppel-like factors in cancer
Reads0
Chats0
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
More filters
Journal ArticleDOI
MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression
Zong-Hui Zhang,Xiaoliang Zhu +1 more
TL;DR: In this paper , the influence of miR-103a-3p on the growth and apoptosis of colorectal cancer (CRC) cells was investigated by using qRT-PCR.
Journal ArticleDOI
Minimal essential region for krüppel-like factor 5 expression and the regulation by specificity protein 3-GC box binding.
TL;DR: It is demonstrated that a 186bp region is the minimal essential region and that Sp3-GC1 binding is essential to the basal expression of KLF5.
Journal ArticleDOI
miR‐92a‐3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis
TL;DR: The results uncovered the miR-92a-3p/KLF2/BIRC5 axis in breast cancer and provided a potential mechanism for breast cancer development, which may serve as promising strategies for Breast cancer therapy.
Journal ArticleDOI
Genomic Biomarkers of Meningioma: A Focused Review
TL;DR: A review of the most common genetic mutations found in meningiomas of all grades, with an emphasis on the impact on tumor location and clinically relevant tumor characteristics, is presented in this article.
Journal ArticleDOI
GLIS1 in Cancer-Associated Fibroblasts Regulates the Migration and Invasion of Ovarian Cancer Cells
TL;DR: Results suggest that CAFs support migration and metastasis of OC cells byGLIS1 overexpression and indicates GLIS1 in CAFs might be a potential therapeutic target to inhibit OC metastasis.
References
More filters
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
Wnt/beta-catenin signaling in development and disease.
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
Journal ArticleDOI
Lessons from Hereditary Colorectal Cancer
TL;DR: The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and to F. Giardiello and S. Hamilton for photographs of colorectal lesions.
Journal ArticleDOI
Phylogeny.fr: robust phylogenetic analysis for the non-specialist
Alexis Dereeper,Valentin Guignon,Guillaume Blanc,Stéphane Audic,S. Buffet,François Chevenet,Jean-François Dufayard,Stéphane Guindon,Vincent Lefort,Magali Lescot,Jean-Michel Claverie,Olivier Gascuel +11 more
TL;DR: The Phylogeny.fr platform transparently chains programs to automatically perform phylogenetic analyses and can also meet the needs of specialists; the first ones will find up-to-date tools chained in a phylogeny pipeline to analyze their data in a simple and robust way, while the specialists will be able to easily build and run sophisticated analyses.
Journal ArticleDOI
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
TL;DR: A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention and provide a paradigm for macrophage plasticity and function.