Journal ArticleDOI
Krüppel-like factors in cancer
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells
Bing Wang,Ming-zhi Zhao,Naipeng Cui,Dan-Dan Lin,An-yi Zhang,Yan Qin,Cai-yun Liu,Wei-tao Yan,Jian-hong Shi,Bao-ping Chen +9 more
TL;DR: Krüppel‐like factor 4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line.
Journal ArticleDOI
Adaptive redox homeostasis in cutaneous melanoma.
TL;DR: Targeting redox homeostasis in melanoma progression remains to be a promising therapeutic approach, especially valid during melanoma drug resistance.
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DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression.
Victoria K. Xie,Zhiwei Li,Yongmin Yan,Zhiliang Jia,Xiangsheng Zuo,Zhenlin Ju,Jing Wang,Jiawei Du,Dacheng Xie,Keping Xie,Daoyan Wei +10 more
TL;DR: This is the first demonstration that dysregulated KLF4 expression associates with poor differentiation of pancreatic cancer.
Journal ArticleDOI
A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus
Daniela Castanotto,Xiaowei Zhang,Jessica Alluin,Xizhe Zhang,Jacqueline Rüger,Brian Armstrong,John J. Rossi,Arthur D. Riggs,Cy A. Stein +8 more
TL;DR: It is demonstrated that cellular stress can significantly increase ON- or siRNA-directed splicing switch events and endogenous miRNA targeting of nuclear RNAs in response to cellular stress.
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Concise Review: Regulation of Self-Renewal in Normal and Malignant Hematopoietic Stem Cells by Krüppel-Like Factor 4.
TL;DR: The current understanding of the regulation of self‐renewal by KLF proteins in embryonic stem cells is summarized and the potential function of KLF4 in normal hematopoietic stem cells and its emerging role in leukemia‐initiating cells from pediatric patients with T‐cell acute lymphoblastic leukemia via repression of the mitogen‐activated protein kinase 7 pathway is delved into.
References
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