Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Journal ArticleDOI
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma.
Wenxian Hu,Wayne L. Hofstetter,Hong Li,Yanbin Zhou,Yong He,Abujiang Pataer,Li Wang,Keping Xie,Stephen G. Swisher,Bingliang Fang +9 more
TL;DR: The results suggest that KLF4 plays an important role in suppressing the growth of lung carcinoma.
Journal ArticleDOI
Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis
Han Ton-That,Han Ton-That,Klaus H. Kaestner,Klaus H. Kaestner,Janiel M Shields,Janiel M Shields,Channing S Mahatanankoon,Channing S Mahatanankoon,Vincent W Yang,Vincent W Yang +9 more
TL;DR: The findings indicate that GKLF expression correlates with certain periods of gut development and is down‐regulated during intestinal tumorigenesis, suggesting that GkLF may play a role in Gut development and/or tumor formation.
Journal ArticleDOI
Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.
Saku Miyamoto,Toru Suzuki,Shinsuke Muto,Kenichi Aizawa,Akatsuki Kimura,Yoshiko Mizuno,Tomoko Nagino,Yasushi Imai,Naruhiko Adachi,Masami Horikoshi,Ryozo Nagai +10 more
TL;DR: A new pathway for regulation of a DNA-binding transcription factor on the DBD is suggested through interaction and coupled acetylation by two opposing regulatory factors of a coactivator/acetylase and a negative cofactor harboring activity to inhibit acetylations.
Journal ArticleDOI
KLF8 transcription factor participates in oncogenic transformation
Xianhui Wang,Jihe Zhao +1 more
TL;DR: Results indicate that KLF8 is required for v-Src-induced transformation and may play a role in tumor progression of human cancer.
Journal ArticleDOI
KLF4 Interacts with β-Catenin/TCF4 and Blocks p300/CBP Recruitment by β-Catenin
TL;DR: The molecular mechanisms of KLF4-mediated inhibition of Wnt/β-catenin signaling are characterized, which provide a deeper understanding of the regulation of β- catenin in the intestine and will have important implications in cancer and stem cell research.