Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Curcumin-mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro.
TL;DR: It is hypothesized that curcumin‐mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoters could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence ofCurcumin and thus its therapeutic implications could further be investigated.
Journal ArticleDOI
Preclinical Targeting of MicroRNA-214 in Cutaneous T-Cell Lymphoma
Rebecca Kohnken,Betina McNeil,Jing Wen,Kathleen McConnell,Leah Grinshpun,Ashleigh Keiter,Luxi Chen,Basem M. William,Pierluigi Porcu,Anjali Mishra +9 more
TL;DR: It is proposed that the TWIST1/BRD4/miR-214 regulatory loop is an important, targetable, oncogenic pathway in CTCL, supporting further investigation of epigenetic dysregulation and miR-driven oncogenesis in this disease.
Journal ArticleDOI
Krüppel-like factors in breast cancer: Function, regulation and clinical relevance
TL;DR: Current knowledge of the functions, regulations and clinical relevance of KLFs in breast cancer will be summarized to indicate their promising prognostic and predictive potential for breast cancer survival and outcome.
Journal ArticleDOI
A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy.
Zhuan Zhou,Zhiwei Feng,Dong Hu,Peng Yang,Mert Gur,Ivet Bahar,Massimo Cristofanilli,William J. Gradishar,Xiang-Qun Xie,Yong Wan +9 more
TL;DR: The potent effect for WX2–43 in inhibiting PRMT5-KLF4 binding that, in turns, suppresses tumor progression and induces tumor cell death in both TNBC cultured-cell and animal models is characterized.
Journal ArticleDOI
Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning
TL;DR: The results suggest that Klf factors are involved in the fine‐tuning of these genes during early embryogenesis, as well as in the regulation of key developmental signals.
References
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