Journal ArticleDOI
Krüppel-like factors in cancer
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Kruppel-like Factors in Skeletal Physiology and Pathologies
TL;DR: Kruppel-like transcription factors (KLFs) belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap gene Krüppel as mentioned in this paper .
Posted ContentDOI
Focal DNA hypo-methylation in cancer is mediated by transcription factors binding
TL;DR: In this paper, the authors perform a rigorous bioinformatic analysis integrating the massive amount of data available from The Cancer Genome Atlas to identify transcription factors driving aberrant DNA methylation.
Journal ArticleDOI
Expression and clinical significance of threonine and tyrosine protein kinase (TTK) in osteosarcoma
TL;DR: TTK expression in OS tissue was significantly higher than in normal tissue, it may provide additional help for the early diagnosis or even therapeutic target of OS, and the internal mechanism still needs further investigation.
Journal ArticleDOI
Krüppel-like factors in bone biology.
TL;DR: The krüppel-like factor (KLF) family is a group of zinc finger transcription factors and contributes to different cellular processes such as differentiation, proliferation, migration, and apoptosis as discussed by the authors .
Posted Content
Uncertainty Estimation in Cancer Survival Prediction.
TL;DR: This work proposes a Bayesian framework for survival models that not only gives more accurate survival predictions but also quantifies the survival uncertainty better.
References
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