Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
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Journal ArticleDOI
TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth
Tiffany Cook,Raul Urrutia +1 more
TL;DR: A novel family of zinc finger transcription factors from the exocrine pancreas that participate in the TGF-beta response and inhibit epithelial cell proliferation are described, becoming key players in the regulation of pancreatic cell growth.
Journal ArticleDOI
Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer.
Xiangyu Kong,Lei Li,Zhao-Shen Li,Xiangdong Le,Chen Huang,Zhiliang Jia,Jiujie Cui,Suyun Huang,Liwei Wang,Keping Xie +9 more
TL;DR: It is shown that overexpression of specific FOXM1 isoforms critically regulates pancreatic cancer development and progression by enhancing tumor cell invasion and metastasis.
Journal ArticleDOI
Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5.
Shunsuke Ohnishi,Friedrich Laub,Nobuyuki Matsumoto,Masahiro Asaka,Francesco Ramirez,Teruhiko Yoshida,Masaaki Terada +6 more
TL;DR: Examination of the developmental expression of the mouse Klf5 gene and compared it to the established pattern of the Klf4 gene revealed that the two genes are expressed in both overlapping and mutually exclusive patterns.
Journal ArticleDOI
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors.
Karolina Edlund,Ola Larsson,Adam Ameur,Ignas Bunikis,Ulf Gyllensten,B. Leroy,Magnus Sundström,Patrick Micke,Johan Botling,Thierry Soussi +9 more
TL;DR: An analysis of the latest version of the TP53 mutation database, including 34,453 mutations, obtained a quality score for each report contributing to the database and validated the entire TP53 gene from various types of cancer using next-generation sequencing with ultradeep coverage.
Journal ArticleDOI
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.
Alec C. Kimmelman,Rui F. Qiao,Goutham Narla,Asoka Banno,Nelson Lau,Paula D Bos,Nelson Nuñez Rodriguez,Bertrand C. Liang,Abhijit Guha,John A. Martignetti,Scott L. Friedman,Andrew K Chan +11 more
TL;DR: It is reported that the expression of KLF6 is attenuated in human GBM when compared with primary astrocytes, providing the first evidence of functional tumor suppression by KFL6.