Journal ArticleDOI
Krüppel-like factors in cancer
Reads0
Chats0
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
More filters
Journal ArticleDOI
Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis.
Zhicheng Zeng,Yuling Li,Yangjian Pan,Xiaoliang Lan,Fuyao Song,Jingbo Sun,Kun Zhou,Xiaolong Liu,Xiaoli Ren,Feifei Wang,Jinlong Hu,Xiaohui Zhu,Wei Yang,Wenting Liao,Guoxin Li,Yanqing Ding,Li Liang +16 more
TL;DR: It is shown that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis.
Journal ArticleDOI
Nrf2 Amplifies Oxidative Stress via Induction of Klf9
Shoshanna N. Zucker,Emily E. Fink,Archis Bagati,Sudha Mannava,Anna Bianchi-Smiraglia,Paul N. Bogner,Joseph A. Wawrzyniak,C E Foley,Katerina I. Leonova,Melissa J. Grimm,Kalyana Moparthy,Yurij Ionov,Jianmin Wang,Song Liu,Sandra Sexton,Eugene S. Kandel,Andrei V. Bakin,Yuesheng Zhang,Naftali Kaminski,Brahm H. Segal,Mikhail A. Nikiforov +20 more
TL;DR: It is demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice and identified as a ubiquitous regulator of oxidative stress and lung injury.
Journal ArticleDOI
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Roberto Cuttano,Noemi Rudini,Luca Bravi,Monica Corada,Costanza Giampietro,Eleanna Papa,Marco Francesco Morini,Luigi Maddaluno,Nicolas Baeyens,Ralf H. Adams,Mukesh Mk Jain,Gary Gk Owens,Martin A. Schwartz,Maria Grazia Lampugnani,Elisabetta Dejana +14 more
TL;DR: It is reported that Ccm1 ablation leads to the activation of a MEKK3‐MEK5‐ERK5-MEF2 signaling axis that induces a strong increase in Kruppel‐like factor 4 (KLF4) in ECs in vivo, and this data unveil KLF4 as a therapeutic target for CCM.
Journal ArticleDOI
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.
Dong Hu,Mert Gur,Zhuan Zhou,Armin M. Gamper,Mien Chie Hung,Naoya Fujita,Li Lan,Ivet Bahar,Yong Wan +8 more
TL;DR: A critical role is pointed to for aberrant KLF4 regulation by PRMT5 in genome stability and breast carcinogenesis through structure-based modelling and simulations.
Journal ArticleDOI
Krüppel-like factors in mammalian stem cells and development
TL;DR: An overview of Krüppel-like factors, a family of zinc-finger transcription factors that play fundamental roles in development and stem cell biology, as revealed by studies of animal models is provided.
References
More filters
Journal ArticleDOI
Genetic alterations of the KLF6 gene in colorectal cancers.
Yong Gu Cho,Byung Jun Choi,Chang Jae Kim,Jae Whie Song,Su Young Kim,Suk Woo Nam,Sug Hyung Lee,Nam Jin Yoo,Jung Young Lee,Won Park +9 more
TL;DR: The data support that the KLF6 gene may be one of the candidate tumor suppressor genes in colorectal cancers and that genetic alteration of the KLf6 gene might play a role in the development of coloreCTal carcinomas.
Journal ArticleDOI
Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells.
TL;DR: It was observed that knockdown of KLF8 reduced the cellular proliferation of SGC-7901 gastric cancer cells, a phenotype at least partially due to cell cycle arrest at G1 phase and increased apoptosis, and the inhibition of KLf8 reduces the invasion rates of the cancer cells.
Journal ArticleDOI
Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells
Lei Jiang,Yiu-Kay Lai,Jinfang Zhang,Chu-yan Chan,Gang Lu,Marie Cm Lin,Ming-Liang He,Ji-Cheng Li,Hsiang-Fu Kung +8 more
TL;DR: The data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells, and stathmin promoter activity was inhibited byTIEG1 in a dose-dependent manner.
Journal ArticleDOI
KLF6 Gene and Early Melanoma Development in a Collagen I-Rich Extracellular Environment
Sung Jin Huh,Yen Liang Chen,Scott L. Friedman,Jason Liao,H.-J. Su Huang,Webster K. Cavenee,Gavin P. Robertson +6 more
TL;DR: In melanoma cells, the tumor suppressor gene at 10p15 appears to be KLF6 and signaling from the collagen I-rich extracellular matrix seems to be involved in the tumor suppressive activity of KLF 6 protein.