Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription
Yang Gao,Yang Gao,Kaijie Wu,Kaijie Wu,Yule Chen,Yule Chen,Jiancheng Zhou,Chong Du,Qi Shi,Shan Xu,Shan Xu,Jing Jia,Xiaoshuang Tang,Feng Li,Ke Hui,Dalin He,Dalin He,Peng Guo,Peng Guo +18 more
TL;DR: It is found that KLF5 was essential for cancer cell-endothelial cell interaction in vitro and tumor angiogenesis in nude mice based on lentivirus-mediated KLf5 knockdown bladder cancer cell models and two pivotal pathways in bladder cancer, RTKs/RAS/MAPK and PI3K/Akt, might convey their oncogenic signaling through KLF 5-VEGFA axis.
Journal ArticleDOI
miR-145-5p affects the differentiation of gastric cancer by targeting KLF5 directly.
TL;DR: The role of miR-145-5p/Kruppel-like factor 5 (KLF5) in the pathologic processes of many types of cancer remains unknown as mentioned in this paper.
Journal ArticleDOI
The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis.
Xingyun Wang,Xingyun Wang,Shilin Xia,Hongchang Li,Xiang Wang,Chaonan Li,Yulin Chao,Lingqiang Zhang,Chuanchun Han +8 more
TL;DR: It is demonstrated that USP10 is a critical regulator of KLF4, pinpointing USP 10-KLF4-TIMP3 axis as a promising therapeutic target in lung cancer.
Journal ArticleDOI
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
Yun-Han Huang,Yun-Han Huang,Jing Hu,Fei Chen,Nicolas Lecomte,Harihar Basnet,Charles J. David,Matthew Witkin,Peter J. Allen,Steven D. Leach,Travis J. Hollmann,Christine A. Iacobuzio-Donahue,Joan Massagué +12 more
TL;DR: PDAs that develop with the TGF-β pathway intact avert this apoptotic effect via Inhibitor of Differentiation 1 (ID1), which is identified as a crucial node and potential therapeutic target in PDA.
Journal ArticleDOI
APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.
Andrea Local,Hongying Zhang,Khalid Benbatoul,Peter Folger,Xia Sheng,Cheng-Yu Tsai,Stephen B. Howell,William G. Rice +7 more
TL;DR: The effect of APTO-253 on MYC expression and its downstream target genes, on cell-cycle arrest, DNA damage, and stress responses can be explained by the action of Fe(253)3 and APTO -253 on G-quadruplex DNA motifs.
References
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