Journal ArticleDOI
Krüppel-like factors in cancer
TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
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Journal ArticleDOI
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma
Amy J Voedisch,Dmitry Livanov +1 more
TL;DR: In this paper , the authors showed that KLF2 was markedly downregulated in human retinoblastoma (RB) tissue compared with retina, and that the KLF overexpression significantly inhibited RB cell proliferation and decreased proliferating cell nuclear antigen (PCNA) expression.
Journal ArticleDOI
SP and KLF Transcription Factors in Cancer Metabolism
TL;DR: The role of SP and KLF transcription factors in the metabolism of various cancers and their impact on tumorigenesis is highlighted and a better understanding of the role and underlying mechanisms governing the metabolic changes during tumors could provide new therapeutic opportunities for cancer treatment.
Journal ArticleDOI
Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
TL;DR: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC and is more significant in patientsWith a history of betel quid chewing or with a low T-value.
Journal ArticleDOI
Romidepsin hepatocellular carcinoma suppression in mice is associated with deregulated gene expression of bone morphogenetic protein and Notch signaling pathway components.
Hara Afaloniati,Theofilos Poutahidis,Alexander Giakoustidis,Athanasios Apostolos Gargavanis,Dimitrios Giakoustidis,Katerina Angelopoulou +5 more
TL;DR: In this paper, the effect of Romidepsin-treatment on gene expression levels of components of Bmp and Notch signaling pathways, which are both known to be aberrantly regulated in hepatocarcinogenesis, was investigated.
DissertationDOI
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
TL;DR: The purpose of this present study was to interrogate the role of KLF 6 in ccRCC, and dissect the KLF6-regulated transcriptional networks and how they can contribute in supportingccRCC pathogenesis.
References
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