Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
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Krüppel-like Factor 13 Promotes HCC Progression by Transcriptional Regulation of HMGCS1-mediated Cholesterol Synthesis
TL;DR: In this article , the role and potential molecular mechanism of KLF13 in the growth and migration of liver cancer cells was explored, where the authors used real-time quantitative polymerase chain reaction (qPCR) and western blotting to detect mRNA and protein expression in HCC tissues and cells.
Journal ArticleDOI
Characterization and Spatiotemporal Expression of Klf4 in Large Yellow Croaker Larimichthys crocea.
TL;DR: The spatiotemporal expression patterns of Lc-Klf4 illustrated that Klf4 involves in spermatogenesis, embryogenesis, and adult physiological processes.
Journal Article
The aberrant expressions of MACC1, ZEB1, and KLF4 in hepatocellular carcinoma and their clinical significance.
TL;DR: Positive expressions of MACC1, ZEB1, and KLF4 should be correlated with the duration of OS in patients with HCC and considered promising prognostic biomarkers, as well as potential therapeutic targets for HCC.
Journal ArticleDOI
Silencing KLF16 inhibits oral squamous cell carcinoma cell proliferation by arresting the cell cycle and inducing apoptosis.
TL;DR: In this paper, the role of KLF16 in oral squamous cell carcinoma (OSCC) remains unknown, and the authors conducted a study to investigate its related mechanism.
Journal ArticleDOI
KLF16 inhibits PEDV replication by activating the type I IFN signaling pathway.
Sujie Dong,Ning Kong,H. Shen,Youwen Li,Wen-Zhen Qin,Huanjie Zhai,Xueying Zhai,Xinyu Yang,Chenqian Ye,Manqing Ye,Chang-Hui Liu,Lingxue Yu,Hao Zheng,Wu Tong,Hai Yu,Wen Juan Zhang,Guangzhi Tong,Tongling Shan +17 more
TL;DR: In this paper , the role of KLF16 in viral replication and the signaling mechanism of type I IFN was investigated and it was found that over-expression of KLf16 inhibited the replication of porcine epidemic diarrhea virus (PEDV) through the type I ILP signaling pathway.
References
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