Journal ArticleDOI
Krüppel-like factors in cancer
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TLDR
The roles and regulation of the 17 known KLFs in various cancer-relevant processes are discussed, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types.Abstract:
Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology.read more
Citations
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Journal ArticleDOI
KLF4 p.A472D Mutation Contributes to Acquired Resistance to Cetuximab in Colorectal Cancer
Song Ye,Xiaoge Hu,Chao Ni,Weiwei Jin,Yaping Xu,Lianpeng Chang,Huaixiang Zhou,Jiahong Jiang,Liu Yang +8 more
TL;DR: Functional study of Krüppel-like factor 4 (KLF4) p.A472D revealed increased cetuximab resistance in colorectal cancer cells, which was associated with the increased phosphorylation of downstream EGFR signaling proteins, suggesting that KLF4 p.
Journal ArticleDOI
KLF4 suppresses the proliferation and metastasis of NSCLC cells via inhibition of MSI2 and regulation of the JAK/STAT3 signaling pathway
Diping Luo,Feng Zhao +1 more
TL;DR: In this article , the authors investigated the function of Krüppel-like factor 4 (KLF4) in non-small cell lung cancer (NSCLC) and found that KLF4 significantly inhibited the proliferation, invasion and migration of NSCLC cells via inactivation of MSI2/JAK2/STAT3 signalling pathway.
Journal ArticleDOI
KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers
TL;DR: A description of one of the recently revealed genes, KLF5, which seems to be a promising target for therapeutic intervention in the most widespread type of pancreatic cancer, ductal adenocarcinoma is described.
Book ChapterDOI
Neural Transcription Factors in Disease Progression.
TL;DR: This chapter will review how neuronal transcription factors play a part in inducing a plastic stage in prostate cancer cells that eventually progresses to a more aggressive state such as NEPC.
Journal ArticleDOI
Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL.
Wen-Hsin Liu,Paulina Mrozek-Gorska,Anna-Katharina Wirth,Tobias Herold,Larissa Schwarzkopf,Dagmar Pich,Kerstin Völse,M. Camila Melo-Narváez,Michela Carlet,Wolfgang Hammerschmidt,Irmela Jeremias +10 more
TL;DR: Genetic engineering of PDX models allows the examination of the function of dysregulated genes like KLF4 in a highly clinically relevant translational context, and it enables the selection of therapeutic targets in individual tumors and links their functions to clinically available drugs, which will facilitate personalized treatment in the future.
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