Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Emergency Department Visits for Serious Diagnoses During the COVID-19 Pandemic.
Howard S. Kim,Daniel S. Cruz,Michael J. Conrardy,Kumar R. Gandhi,Justin A. Seltzer,Timothy M. Loftus,Abra L. Fant,Danielle M. McCarthy +7 more
TL;DR: The coronavirus disease 2019 (COVID-19) pandemic has significantly affected health care utilization in the United States and reductions in routine outpatient visits and elective procedures were intentional but this reduction may have been driven by a public fear of seeking care.
Journal ArticleDOI
Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review.
TL;DR: Most of the animal models of CO VID-19 recapitulated mild pattern of human COVID-19 with full recovery phenotype, suggesting a wide gap between COVID -19 in humans and animal models.
Journal ArticleDOI
Prenatal exposure to viral infection and neuropsychiatric disorders in offspring: A review of the literature and recommendations for the COVID-19 pandemic.
TL;DR: The current understanding of the possible neurotropism and vertical transmission of SARS-CoV-2 is discussed, and this is related to the history of viral pandemics to better understand the relationship of viral infection, aberrant immune response and neurodevelopment, and the risk for schizophrenia disorder.
Journal ArticleDOI
Arterial thrombotic complications in COVID-19 patients
TL;DR: These findings demonstrate that physicians should be vigilant for signs of thrombotic complications in both hospitalized and new COVID-19 patients and demonstrate that the coronavirus disease 2019 has been described to predispose to thromBotic disease in both the venous and arterial circulation.
Journal ArticleDOI
Lung megakaryocytes display distinct transcriptional and phenotypic properties.
Anthony K. Yeung,Carlos Villacorta-Martin,Stephanie Hon,Stephanie Hon,Jason R. Rock,Jason R. Rock,George J. Murphy +6 more
TL;DR: Findings support the notion that the lung plays an independent role in the development and functional maturation of MKs, and highlight the existence of a lung-specific MK phenotype that is skewed toward roles in immunity and inflammation.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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